Two British scientists, Dr Ashley Croft and Dr Andrew Herxheimer, have published a paper which for the first time tries to explain the adverse effects of the controversial antimalaria drug, mefloquine (Lariam®).
Mefloquine, made by the Swiss drug company Hoffmann-La Roche, is used both to treat and prevent malaria. Since the 1980s doctors have used it to treat around 2 million people with malaria, and about 15 million travellers have used mefloquine as malaria prophylaxis.
Although many mefloquine users tolerate the drug well, in others it can cause a wide range of neuropsychiatric and other disturbing side effects, including hallucinations, nightmares, anxiety, tremor and psychosis. The first randomised controlled trial of mefloquine use in general travellers was published late last year in Clinical Infectious Diseases. One-third of the travellers using mefloquine reported neuropsychiatric adverse effects, and 6% of all mefloquine users reported at least one adverse event serious enough to require medical advice.
Andrew Herxheimer | alphagalileo
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
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