Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antidepressants and painkillers – a dangerous combination

09.10.2007
Taking antidepressants together with painkillers can substantially increase the risk of bleeding from the stomach, according to new research by the University of East Anglia.

The antidepressant drugs, selective serotonin reuptake inhibitors known as SSRIs, are recommended by the National Institute of Clinical Excellence (NICE). SSRIs are very widely used in the UK, with more than 18 million prescriptions issued last year, probably to about 1.5 million patients.

Painkillers such as ibuprofen are widely used by the public and can be purchased from supermarkets and pharmacies without prescription.

The new research was undertaken by Dr Yoon Loke, a clinical pharmacologist at UEA’s School of Medicine, Health Policy and Practice, working with colleagues at Wake Forest University in the US. The results are published in the journal Alimentary Pharmacology & Therapeutics.

There have been existing concerns over SSRIs harming the stomach, but the threat from combined SSRI and painkiller use had not previously been established. The new UEA research confirms that SSRIs double the risk of bleeding from the stomach, but when taken together with painkillers, the risk increases by six times.

The findings are based on a meta-analysis of 4 studies covering more than 153,000 patients, which estimates that over a period of one year, one in every 106 patients taking SSRIs together with painkillers will require hospital admission due to bleeding in the stomach.

“While the SSRIs on their own carry only a small risk of harm, this risk becomes much more serious when they are taken in combination with painkillers,” said Dr Loke.

The researchers also looked in detail at more than 100 cases of patients who suffered bleeding in the stomach related to SSRIs and found that two-thirds of the patients were taking painkillers at the same time.

“If you have a history of stomach ulcers or indigestion then SSRIs may not be the best choice for treating your depression,” said Dr Loke. “There are other antidepressants which seem to be less harmful.”

He also advised patients on SSRIs: “If you do need to take a painkiller, drugs such as paracetamol may be a safer choice, rather than the non-steroidal anti-inflammatory drugs like ibuprofen.”

Dr Loke’s co-researchers were Dr Sonal Singh and Dr Apurva Trivedi, both of Wake Forest University School of Medicine in the US.

Press Office | alfa
Further information:
http://www.uea.ac.uk

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>