In the search for better ways of treating children with brain cancer the study, carried out by the Children’s Cancer and Leukaemia Group at The University of Nottingham, revealed that a significant proportion of children under the age of three, with the brain tumour ependymoma, can be spared, or have delayed, the effects of radiotherapy by using chemotherapy — without compromising their chances of survival. The trial results were published in the Lancet Oncology on 20th July, 2007.
Experts in the field of childhood cancer recognise that radiotherapy can be harmful to a young child’s developing brain. It can affect IQ, short term memory, growth and puberty. The effective treatment of patients under the age of five remains, say the researchers, one of the more difficult tasks in paediatric oncology.
The trial was funded by Cancer Research UK and the Samantha Dickson Brain Tumour Trust. The study’s author, Professor Richard Grundy, from the Children’s Brain Tumour Research Centre (CBTRC), at The University of Nottingham said: “We know that radiotherapy can be harmful to the developing brain, so avoiding it, or using it at an older age if needed will hopefully reduce any learning difficulties these children may develop without compromising their chance of a cure”.
Every year over 450 children are diagnosed with a brain tumour in the UK. Established in 1997 the CBTRC is committed to developing new methods of research to help find a cure whilst minimising the risk of disability.
The survival rate for children diagnosed with ependymoma is getting better, but remains unacceptably low. Professor Grundy said: “It is now clear that if we are to improve the outcome for children with ependymoma we need a better understanding of the underlying biology of the disease.” Research fellows in Professor Grundy’s laboratory at the CBTRC are currently involved in a collaborative project with St Jude Children's Research Hospital in the USA and the Hospital for Sick Children to gain a better understanding of the biology of this disease in the hope of improving outcomes.
Emma Thorne | alfa
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy