Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research shows way to how cells breathe

29.05.2007
Inhaling oxygen is only the first step in a long journey through the nooks and crannies of the body. The oxygen is then transported via the blood to all cells in the body. The same goes for nourishment from food we eat.

Inside the cell, the oxygen and nourishment are transformed into energy and carbon dioxide, which we breathe out. In a new dissertation from Stockholm University in Sweden, Kristina Faxén has mapped how so-called cell breathing takes place.

"I am studying how cells breathe. In recent years, more and more diseases, like Alzheimer's, have shown to have to do with cell respiration. The findings are expected ultimately to lead to drugs specifically designed for various disorders, although that's far down the road," says Kristina Faxén, a doctoral candidate at the Department of Biochemistry and Biophysics at Stockholm University in Sweden.

Every cell contains many tiny energy power plants -­ the mitochondria. The enzymes that govern cell breathing are located in membranes that surround the mitochondria. Kristina Faxén has analyzed one of these enzymes-­cytochromoxidase. This is a pump that distributes positive and negative charges to opposite sides of the membrane, thereby functioning roughly like a battery charger that helps to "charge our inner batteries." These batteries power all bodily functions, such as our muscles, brain, and digestion.

"To study this 'battery charger' my colleagues and I have managed to construct artificial cells consisting of a globe-shaped membrane, something like a soap bubble, but only 30 nanometers (millionths of a millimeter) in diameter. Then we introduced cytochromoxidase to the membrane. In this way, it can function just as in a living cell," she says.

One thing that makes the reaction difficult to study is how quickly it happens. A single 'breath' in the cell takes only a thousandth of a second. The laboratory at Stockholm University is one of the few in the world that possesses the advanced laser technology needed to study such rapid processes.

"Several research teams around the world have studied molecular pumps, trying to understand how they work. But there has been no unanimity about any general mechanism. Our findings have solved some of the conflicts. Previously we presented an extremely simple and general principle for the functioning of the pumps that shows how a swinging arm fetches positive charges, protons, on one side of the membrane and leaves them on the other side. The findings of my dissertation support this model," says Kristina Faxén.

Link to posting of dissertation information: http://www.diva-portal.org/su/abstract.xsql?dbid=6806

For further information, please contact:
Kristina Faxén, doctoral candidate, Department of Biochemistry and Biophysics, Stockholm University, phone: +46 (0)8-16 27 15; cell phone: +46 (0)734-388357; e-mail: Kristina.Faxen@dbb.su.se

Maria Erlandsson | idw
Further information:
http://www.diva-portal.org/su/abstract.xsql?dbid=6806

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>