Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Treatment of kidney condition requires an individualised approach

15.05.2007
Good patient information is essential for choosing the best treatment for the kidney disease lupus nephritis. Dutch researcher Cecile Grootscholten concludes this following her doctoral research into two methods for treating lupus nephritis. She did not demonstrate any major differences but both treatments have pros and cons.

The severity of the kidney disease lupus nephritis varies and the side effects of the treatments differ as well. Therefore Grootscholten advises doctors to thoroughly inform patients in advance about the pros and cons of both treatments. Based on his/her own situation every patient can make a well-considered choice for one of the two treatments.

Grootscholten treated two groups of patients for two years with either drips containing cyclophosphamide (treatment 1) or a combination of drips containing prednisone and oral azathioprine (treatment 2). After 2 years all of the patients were further treated with a low dose of oral prednisone and azathioprine.

Kidney function

The majority of patients faired better than the researchers had expected at the start of the study in 1995. Grootscholten observed that the chance of the disease recurring in the kidneys was greater in the group of patients treated with treatment 2. Shingles also occurred more frequently in this group. However, Grootscholten could not demonstrate a difference between treatment 1 and treatment 2 in terms of long-term kidney function. Moreover in the end, just as many people needed dialysis.

Quality of life

Treatment 1 was experienced as heavier than treatment 2. Yet there were no differences in terms of quality of life or complaints. Treatment 1 is known to increase the risk of infertility and early menopause. Therefore treatment 2 remains as an alternative. A more extensive study is needed for more concrete statements.

Lupus nephritis

Lupus nephritis is a severe kidney inflammation caused by the autoimmune disease systemic lupus erythematodes. The body produces antibodies against its own organs and treatment is absolutely necessary. The condition is rare. Each year 6 in every 100,000 people in the Netherlands develop the disease. Up until 40 years ago patients died from lupus nephritis. Since then various treatment methods have been sought to suppress the inflammation in the kidney. To date no thorough research into the differences between these methods had been carried out.

Dr Cecile Grootscholten | alfa
Further information:
http://www.nwo.nl/nwohome.nsf/pages/NWOA_6ZYL6T_Eng

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>