Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immunocompatibility Of Happy Parents

07.05.2007
Occurrence and gravity of toxicosis with the pregnant depends on the married couple's immunological compatibility. As has been proved by the specialists of the department of clinical immunology and division of pathology of the pregnant (Research Center for Obstetrics, Gynaecology and Perinatology, Russian Academy of Medical Sciences), coincidence in some antigens has pernicious influence on the pregnancy course and the infant’s health.

Genes of the main histocompatibility complex (called HLA with human beings) are responsible for recognition of alien proteins. These genes are numerous, and their variety is wide. When a person is to select a donor for transplantation, the donor is looked for by HLA-compatibility in particular. Coincidence in all known HLA antigens is a practically impossible event, however, it is sufficient to select a pair for transplantation which coincides in several HLA gene sequences. Physicians have recently found out that the HLA genes influence some reproductive disorders, however, the data on such impact is still contradictory.

The Moscow researchers have investigated the influence of the conjoints’ histocompatibility rate on the toxicosis development and gravity in the second half of pregnancy. They observed the course of pregnancy with 27 married couples, where the current or previous pregnancy proceeded with toxicosis, and 10 couples with physiological course of pregnancy, who made the reference group.

It has turned out that toxicosis occurs more frequently with women who have more than two identical HLA gene sequences with the child’s father. The coincidences were discovered with all the couples in the main group, while in the reference group – they were discovered in less than a half of cases. The more coincidences were between the husband and wife (in the large number of HLA gene sequences), the higher the gravity of toxicosis was. In the reference group, the number of coincidences was no more than two.

From the immunology perspective, the fetus is a transplant. Half of its genes is obtained from the father, therefore, a lot of fetus’ proteins are perceived by the mother’s organism as alien ones and should be rejected. However, the rejection does not happen as in the normal pregnancy course as the mother’s immune system transforms and becomes “tolerant” to the alien embryo. The difference in some loci of HLA-genes of the mother and the fetus becomes the very signal that sets the woman’s immune system to pregnancy. If the mother and the future child have turned out to be histocompatible, the immune system does not change, and the mother’s organism may reject the fetus. That is why a lot of specialists consider toxicosis as a clinical form of the fetus rejection in the second half of pregnancy.

In case of toxicosis, placenta develops improperly and is poorly supplied with blood, as it insufficiently grows into the womb tissue. As a result, the fetus suffers from the lack of oxygen and nutrients, and infants are born impaired and with deficiency in weight (they can even die in case of grave toxicosis). The histocompatibility analysis of married couples allows physicians to significantly enhance the notion of immunological component, toxicosis origin and its course. However, it can hardly be expected that in the near future the father for the future child will be selected as scrupulously as the donor for transplantation.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Magnesium magnificent for plasmonic applications

23.05.2018 | Materials Sciences

Tunable diamond string may hold key to quantum memory

23.05.2018 | Physics and Astronomy

Building a brain, cell by cell: Researchers make a mini neuron network (of two)

23.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>