Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immunocompatibility Of Happy Parents

07.05.2007
Occurrence and gravity of toxicosis with the pregnant depends on the married couple's immunological compatibility. As has been proved by the specialists of the department of clinical immunology and division of pathology of the pregnant (Research Center for Obstetrics, Gynaecology and Perinatology, Russian Academy of Medical Sciences), coincidence in some antigens has pernicious influence on the pregnancy course and the infant’s health.

Genes of the main histocompatibility complex (called HLA with human beings) are responsible for recognition of alien proteins. These genes are numerous, and their variety is wide. When a person is to select a donor for transplantation, the donor is looked for by HLA-compatibility in particular. Coincidence in all known HLA antigens is a practically impossible event, however, it is sufficient to select a pair for transplantation which coincides in several HLA gene sequences. Physicians have recently found out that the HLA genes influence some reproductive disorders, however, the data on such impact is still contradictory.

The Moscow researchers have investigated the influence of the conjoints’ histocompatibility rate on the toxicosis development and gravity in the second half of pregnancy. They observed the course of pregnancy with 27 married couples, where the current or previous pregnancy proceeded with toxicosis, and 10 couples with physiological course of pregnancy, who made the reference group.

It has turned out that toxicosis occurs more frequently with women who have more than two identical HLA gene sequences with the child’s father. The coincidences were discovered with all the couples in the main group, while in the reference group – they were discovered in less than a half of cases. The more coincidences were between the husband and wife (in the large number of HLA gene sequences), the higher the gravity of toxicosis was. In the reference group, the number of coincidences was no more than two.

From the immunology perspective, the fetus is a transplant. Half of its genes is obtained from the father, therefore, a lot of fetus’ proteins are perceived by the mother’s organism as alien ones and should be rejected. However, the rejection does not happen as in the normal pregnancy course as the mother’s immune system transforms and becomes “tolerant” to the alien embryo. The difference in some loci of HLA-genes of the mother and the fetus becomes the very signal that sets the woman’s immune system to pregnancy. If the mother and the future child have turned out to be histocompatible, the immune system does not change, and the mother’s organism may reject the fetus. That is why a lot of specialists consider toxicosis as a clinical form of the fetus rejection in the second half of pregnancy.

In case of toxicosis, placenta develops improperly and is poorly supplied with blood, as it insufficiently grows into the womb tissue. As a result, the fetus suffers from the lack of oxygen and nutrients, and infants are born impaired and with deficiency in weight (they can even die in case of grave toxicosis). The histocompatibility analysis of married couples allows physicians to significantly enhance the notion of immunological component, toxicosis origin and its course. However, it can hardly be expected that in the near future the father for the future child will be selected as scrupulously as the donor for transplantation.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>