Professor David Lambert, who has been involved in the development the drug in collaboration with Dr Girolamo Calo in Ferrara Italy, believes the new drug – called UFP-101 - avoids many of the side effects of morphine, currently the ‘gold standard’ in pain reduction.
He said: “In a 2005 survey for the British Pain Society 975 people were questioned about pain. Twenty one percent experienced pain every day or most days equating to ~10million across the whole UK.
“Morphine produces its clinical effects by interaction with opioid receptors. In addition to acting as a pain killer this drug produces a number of unwanted side effects of importance from a clinical (e.g., depression of breathing, constipation and tolerance) and social (addiction) viewpoints.
“Clearly there is a place for new morphine like drugs without these side effects and the University of Leicester Anaesthesia Division has been at the forefront of such preclinical research.”
Since appointment in 1991 as a lecturer Professor Lambert has been working on opioids and opioid receptors with particular emphasis on understanding receptor function and the design and evaluation of new drugs to target these receptors.
In collaboration with Dr Girolamo Calo his laboratory has characterised a prototype analgesic (pain killer), acting at a new opioid receptor, with a much reduced side effect profile.
In his inaugural lecture he will describe the current place of opioids in the clinic and development of UFP-101.
Inaugural lecture at 5.30pm on 20th March, Ken Edwards Building, University of Leicester
Alex Jelley | alfa
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
23.02.2017 | Health and Medicine
23.02.2017 | Life Sciences
23.02.2017 | Life Sciences