This study, conducted in conjunction with Professor Maurizio Tonetti (University of Connecticut, USA), and reported in the latest edition of the New England Journal of Medicine, may have relevance for the prevention of heart attacks and stroke.
Periodontitis is a common inflammatory disease of the gums, affecting up to 40 per cent of the world’s adult population. It is a bacterial infection of the tissue that supports the teeth in the mouth. If untreated, it can cause progressive bone loss around the teeth, and eventual tooth loss.
There is already established scientific evidence linking inflammation, the body’s natural response to infection or injury, with the arterial changes that underlie stroke and heart attack. However, this is the first clinical trial to demonstrate that relief of inflammation in the mouth, through intensive treatment of periodontitis, results in improved function of the arteries.
Dr Francesco D’Aiuto, project leader and therapist, UCL Eastman Dental Institute, explained the method behind the research: “Middle-aged subjects with severe periodontitis, but no evidence of cardiovascular disease, were randomly allocated to dental treatments of two levels of intensity. After six months, those who received the more intensive periodontitis treatment, which resulted in a marked improvement in their gum disease, also demonstrated a significant restoration of blood vessel function.
“The intensive treatment involved removal of plaque through scaling and root planning techniques, as well as extraction of teeth that could not be saved. This initially resulted in some inflammation and dysfunction of the blood vessels and arteries. However, that was short-lived and six months later the treatment led to an improvement in both oral health and arterial function.”
Professor John Deanfield, senior author, UCL Institute of Child Health, added: “Previous studies have shown an association between periodontitis and blood vessel dysfunction, heart attack and stroke. However, a clinical trial was required to test whether these links could be causal. This is the first time that a direct link has been made between treatment for gum disease and improved circulatory function, which is relevant to some of the UK’s biggest killers: heart attack and stroke.”
Dr Aroon Hingorani, UCL Division of Medicine, a co-author on the study, set the findings in context: “Elevations in blood pressure and cholesterol, as well as smoking and diabetes, are recognised as the main risk factors for cardiovascular disease, and these can be effectively treated. Nevertheless, heart attacks and stroke remain a major cause of disability and death. Intriguing links have emerged between inflammation and heart disease and so it is important to better understand the nature of this connection, and whether it could lead to the development of new treatments. The current study points to disease of the gums as a potential source of this inflammation.”
Professor Deanfield concluded: “This finding therefore has potential implications for public health, but further studies are now required to determine whether the treatment of severe periodontitis could directly contribute to the prevention of disease of the arteries (atherosclerosis), stroke and heart attacks.”
The mechanism by which periodontitis affects endothelial function in the body is still uncertain. The gum disease involves a bacterial infection that invades the tissue around the teeth. One possibility is that the bacteria disturb endothelial function directly, since some bacteria can enter the bloodstream. Alternatively, the periodontitis might trigger a low grade inflammatory response throughout the body that has a detrimental effect on the vascular wall.
Dominique Fourniol | alfa
Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications
Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine