Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New medical finding: treatment for gum disease could also help the heart

Scientists at University College London (UCL) have conducted the first clinical trial to demonstrate that an intensive treatment for periodontitis (gum disease) directly improves the health of blood vessels.

This study, conducted in conjunction with Professor Maurizio Tonetti (University of Connecticut, USA), and reported in the latest edition of the New England Journal of Medicine, may have relevance for the prevention of heart attacks and stroke.

Periodontitis is a common inflammatory disease of the gums, affecting up to 40 per cent of the world’s adult population. It is a bacterial infection of the tissue that supports the teeth in the mouth. If untreated, it can cause progressive bone loss around the teeth, and eventual tooth loss.

There is already established scientific evidence linking inflammation, the body’s natural response to infection or injury, with the arterial changes that underlie stroke and heart attack. However, this is the first clinical trial to demonstrate that relief of inflammation in the mouth, through intensive treatment of periodontitis, results in improved function of the arteries.

Dr Francesco D’Aiuto, project leader and therapist, UCL Eastman Dental Institute, explained the method behind the research: “Middle-aged subjects with severe periodontitis, but no evidence of cardiovascular disease, were randomly allocated to dental treatments of two levels of intensity. After six months, those who received the more intensive periodontitis treatment, which resulted in a marked improvement in their gum disease, also demonstrated a significant restoration of blood vessel function.

“The intensive treatment involved removal of plaque through scaling and root planning techniques, as well as extraction of teeth that could not be saved. This initially resulted in some inflammation and dysfunction of the blood vessels and arteries. However, that was short-lived and six months later the treatment led to an improvement in both oral health and arterial function.”

Professor John Deanfield, senior author, UCL Institute of Child Health, added: “Previous studies have shown an association between periodontitis and blood vessel dysfunction, heart attack and stroke. However, a clinical trial was required to test whether these links could be causal. This is the first time that a direct link has been made between treatment for gum disease and improved circulatory function, which is relevant to some of the UK’s biggest killers: heart attack and stroke.”

Dr Aroon Hingorani, UCL Division of Medicine, a co-author on the study, set the findings in context: “Elevations in blood pressure and cholesterol, as well as smoking and diabetes, are recognised as the main risk factors for cardiovascular disease, and these can be effectively treated. Nevertheless, heart attacks and stroke remain a major cause of disability and death. Intriguing links have emerged between inflammation and heart disease and so it is important to better understand the nature of this connection, and whether it could lead to the development of new treatments. The current study points to disease of the gums as a potential source of this inflammation.”

Professor Deanfield concluded: “This finding therefore has potential implications for public health, but further studies are now required to determine whether the treatment of severe periodontitis could directly contribute to the prevention of disease of the arteries (atherosclerosis), stroke and heart attacks.”

The mechanism by which periodontitis affects endothelial function in the body is still uncertain. The gum disease involves a bacterial infection that invades the tissue around the teeth. One possibility is that the bacteria disturb endothelial function directly, since some bacteria can enter the bloodstream. Alternatively, the periodontitis might trigger a low grade inflammatory response throughout the body that has a detrimental effect on the vascular wall.

Dominique Fourniol | alfa
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>