These are results of clinical experiments carried out by the specialists of Russian State Medical University and the Clinic of Rehabilitation Intervention Neurology and Therapy “NeuoVita”.
The experiment involved 67 patients of different ages with severe spinal cord injuries. The patients were divided into two groups. The ten patients to whom cellular therapy was contraindicated for different reasons formed a reference group. They only underwent rehabilitation. The rest of the patients, on top of rehabilitation, underwent at least two injections of their own hematopoietic stem cells. Before that they had received a course of injections of granulocytic colony-stimulating factor that ensured additional production of stem cells and their coming out of the marrow into blood vessels. The cells were collected at the blood separator, frozen and used as needed. Each patient was injected about 5 million cells into the vertebral column. The course was repeated to some patients.
The spinal cord trauma impacts both the work of the spinal marrow itself and that of the peripheral nervous system. Several years after the trauma, the nerves gradually degenerate and finally perish. Rehabilitation would not help in this case, the researchers made certain of that again by the example of the reference group, the state of which had not changed. The cellular therapy helped to a significant part of the patients (61 percent). Their muscle activity increased, movements and sensitivity intensified, pelvic organs’ function improved.
After the first cell transplantation, these changes were of minimal extent, however, the second transplantation supported by intensified rehabilitation has done its part. After the second injection of cells was perfomed, many of the 33 patients were able to stand on their knees and to move with the help of “go-carts”. It should be noted that they had not experienced the slightest improvement for several years.
The ecouraging clinical finding was confirmed by the electroneuromyography data that allows to assess quantitatively the muscle response to nervous stimulation. After cell transplantation, there was an increase of the muscle response amplitude to activation of motor nerve fibers of peripheral nerves. This data is an indirect evidence that cellular therapy promotes spinal cord regeneration. Having summarized the findings, physicians concluded that transplantation of the patient’s own hematopoietic stem cells is secure and efficient in conjunction with other treatment modes.
Nadezda Markina | alfa
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
21.03.2018 | Physics and Astronomy
21.03.2018 | Materials Sciences
21.03.2018 | Life Sciences