Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The patients with spinal cord trauma have a ray of hope

22.01.2007
Injection of the patient’s own hematopoietic stem cells promotes restoration of injured spinal cord and disrupted function of the peripheral nervous system.

These are results of clinical experiments carried out by the specialists of Russian State Medical University and the Clinic of Rehabilitation Intervention Neurology and Therapy “NeuoVita”.

The experiment involved 67 patients of different ages with severe spinal cord injuries. The patients were divided into two groups. The ten patients to whom cellular therapy was contraindicated for different reasons formed a reference group. They only underwent rehabilitation. The rest of the patients, on top of rehabilitation, underwent at least two injections of their own hematopoietic stem cells. Before that they had received a course of injections of granulocytic colony-stimulating factor that ensured additional production of stem cells and their coming out of the marrow into blood vessels. The cells were collected at the blood separator, frozen and used as needed. Each patient was injected about 5 million cells into the vertebral column. The course was repeated to some patients.

The spinal cord trauma impacts both the work of the spinal marrow itself and that of the peripheral nervous system. Several years after the trauma, the nerves gradually degenerate and finally perish. Rehabilitation would not help in this case, the researchers made certain of that again by the example of the reference group, the state of which had not changed. The cellular therapy helped to a significant part of the patients (61 percent). Their muscle activity increased, movements and sensitivity intensified, pelvic organs’ function improved.

After the first cell transplantation, these changes were of minimal extent, however, the second transplantation supported by intensified rehabilitation has done its part. After the second injection of cells was perfomed, many of the 33 patients were able to stand on their knees and to move with the help of “go-carts”. It should be noted that they had not experienced the slightest improvement for several years.

The ecouraging clinical finding was confirmed by the electroneuromyography data that allows to assess quantitatively the muscle response to nervous stimulation. After cell transplantation, there was an increase of the muscle response amplitude to activation of motor nerve fibers of peripheral nerves. This data is an indirect evidence that cellular therapy promotes spinal cord regeneration. Having summarized the findings, physicians concluded that transplantation of the patient’s own hematopoietic stem cells is secure and efficient in conjunction with other treatment modes.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Fraunhofer ISE Pushes World Record for Multicrystalline Silicon Solar Cells to 22.3 Percent

25.09.2017 | Power and Electrical Engineering

Usher syndrome: Gene therapy restores hearing and balance

25.09.2017 | Health and Medicine

An international team of physicists a coherent amplification effect in laser excited dielectrics

25.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>