Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


1 in 5 early-stage breast cancer patients may not follow hormonal therapy plan

Postmenopausal women with early-stage, hormone-sensitive breast cancer have a lower risk of disease recurrence when their treatment includes a new class of hormone therapy drugs, yet one out five women prescribed the drugs may not take them regularly, according to a study conducted by researchers at Dana-Farber Cancer Institute and AstraZeneca Pharmaceuticals. Their findings will be presented at the 29th annual San Antonio Breast Cancer Symposium on Saturday, Dec. 16 (Abstract 4044).

"These data are very concerning because hormonal therapy for breast cancer is one of the most effective treatments in all of oncology," said Ann Partridge, MD, MPH, the study's lead author and a breast cancer specialist at Dana-Farber. "Women may be compromising their care, and ultimately their survival, if they do not take these medications as recommended."

Partridge and her colleagues analyzed claims data from three large commercial health plan systems to gauge treatment compliance of more than 7,000 women with early stage-breast cancer who, in addition to their regular treatment, began taking anastrozole.

Anastrozole is part of a new class of drugs, called aromatase inhibitors, that reduces the production of the hormone estrogen by blocking aromatase, an enzyme that converts the hormone androgen into estrogen. Studies have shown that lowering estrogen levels in post-menopausal women with hormone receptor-positive breast cancer can reduce their risk of disease recurrence.

In one of the health plans analyzed, the researchers found that 85 percent (1,275) of the women were still filling their prescriptions a year after anastrozole was first prescribed, but not everyone was doing so on a regular basis. The researchers also looked at the prescription filling habits of the 1,111 women who had been enrolled in the health plan for 12 consecutive months. They determined that, due to inconsistent refills, 19 percent of the women (211) had access to the drug less than 80 percent of the 12-month period after they first filled an anastrozole prescription. These women were considered to be non-adherent to the treatment.

"This study confirms that even patients with cancer may be non-adherent to their treatment," said Partridge, who is also an assistant professor of medicine at Harvard Medical School. "Non-adherence is a very complex issue, and the reasons that a patient may not take her medication as directed can include fear of or the experience of side effects, cost of treatment, and negative health beliefs, like the treatment will not help."

Bill Schaller | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital

nachricht Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>