In a systematic review of previously published studies researchers, Edward Mills and colleagues, looked at studies in both developed and developing country settings which had examined the factors that affect adherence to these regimens.
84 relevant studies were examined of which 37 used “qualitative” methods (focus groups, interviews, open-ended questioning) and 47 used “quantitative” methods (surveys). Only 12 of the studies had been carried out in the developing world.
Many barriers to adherence were common to both developed and developing settings, including fear of disclosure of HIV status, concomitant substance abuse, forgetfulness, suspicions of treatment, regimens that were too complicated, number of pills required, decreased quality of life, and work and family responsibilities. Factors unique to the studies conducted in the developing world included financial constraints and problems with traveling to get access to treatment.
Important facilitators (factors that made adherence easier) reported by patients in developed nation settings included having a sense of self-worth, seeing positive effects of antiretroviral drugs, acceptance of HIV status, understanding of the need for strict adherence, making use of reminder tools, and having a simple regimen. No facilitators to adherence were discussed in any study in a developing nation setting.
The authors conclude that “clinicians should use this information to engage in open discussion with patients to promote adherence and identify barriers and facilitators within their own populations”. However, they note that in developing country settings, “the reliability of medication access is an important adherence barrier that individuals have little opportunity to facilitate. Patient-level adherence can be determined only when a steady supply of medication exists.”
Citation: Mills EJ, Nachega JB, Bangsberg DR, Singh S, Rachlis B, et al. (2006) Adherence to antiretroviral therapy: A systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med 3(11): e438.
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
28.10.2016 | Power and Electrical Engineering
28.10.2016 | Physics and Astronomy
28.10.2016 | Life Sciences