Oestrogens are normally thought of as a female hormone, but recently scientists have found that oestrogens have vital roles to play in men’s health; without estrogens at all men are tall and overweight and develop diabetes. Now scientists are beginning to realise that oestrogen also has a major role to play in the development of the prostate gland and may contribute to common male problems, prostate cancer and BHP.
Prostate cancer is the most common cancer in British men, with more than 30,000 new cases diagnosed every year. 43% of British men over the age of 65 suffer from BHP.
There are two types of receptors for the hormone oestrogen, oestrogen-receptor-alpha and oestrogen receptor-beta. A group of scientists led by Professor Gail Risbridger (Monash University, Melbourne) have tested compounds that selectively activate one but not the other receptor. Thus, they can turn on one receptor eg oestrogen receptor alpha without affecting oestrogen receptor beta and vice versa.
Working in animals, they found that regulating the oestrogen receptor beta was beneficial and stopped the development of prostate hyperplasia. Whereas the bad effects of estrogens are due to activation of the oestrogen receptor alpha and are linked to malignancy.
Presenting her results at the conference in London, Professor Risbridger said
“We still have to try the drugs in humans, but so far these are very promising results. This work holds out the possibility that we may be able to help patients with benign disease as well as men with prostate cancer, by using these designer drugs.
Ideally, we would want to promote the good effects of oestrogen receptor beta and block the bad effects of oestrogen receptor alpha.
It's interesting work, and we are pleased that preclinical testing may translate into real benefits for patients”.The work is being presented at the Society for Endocrinology conference, but it has also just been accepted for publication in the journal Endocrinology; for the abstract of the Endocrinology article, see:
Jo Thurston | alfa
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology