The study appeared in the Sept. 1 issue of the Journal of Clinical Investigation.
In acute lung injury -- usually resulting from infection, inflammation or surgical trauma -- cells that line the blood vessels in the lung lose their ability to form a barrier, allowing fluid to seep into the lung's air spaces and resulting in respiratory failure. Such damage is a significant cause of death in critically ill patients.
Very little is known about how the lung repairs this lining layer, called the endothelium, said You-Yang Zhao, research assistant professor of pharmacology.
"We thought it likely that the ability of cells to repair and restore the endothelium might depend on their ability to proliferate and fill in gaps in the endothelial monolayer barrier that allow leaking," said Zhao, who is lead author of the study.
Earlier studies had shown that FoxM1, a protein that controls the expression of genes, plays a critical role in cell proliferation. Working with the late Robert Costa, professor of biochemistry and molecular genetics at UIC, whose research focused on FoxM1, the researchers developed a mouse model that lacked the FoxM1 gene only in endothelial cells.
In the study, lung injury was induced in normal mice and in the gene-deleted mice. Blood vessels in the FoxM1-deficient mice continued to leak fluid, and the mice were significantly less likely to recover, resulting in a seven-times-greater mortality rate.
Although the immune response of each group was similar, there was less endothelial cell proliferation in the gene-deficient mice after the injury, suggesting that inability to fill the gaps in the barrier with new cell growth impaired the ability to recover.
Asrar Malik, professor and head of pharmacology at UIC, says the results suggest that lung injury activates a repair program, mediated by FoxM1, that encourages cell growth and restores the barrier integrity.
"This suggests future therapies for acute lung injury that target this molecule could promote endothelial regeneration and the patient's recovery," said Malik, who is senior author of the paper.
Jeanne Galatzer-Levy | EurekAlert!
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences