Researchers add that with advances in imaging, almost 70 percent of kidney cancer patients have their tumor detected at a very small size (less than 4 cm), allowing surgeons to perform less radical surgery with superior results.
The study revealed that patients with two otherwise healthy kidneys who underwent kidney-sparing surgery (partial nephrectomy) to remove a small cancer developed chronic kidney disease at a rate one-third lower than patients whose entire kidney was removed (radical nephrectomy). The three-year probability of staying free of chronic kidney disease was 80 percent for the partial nephrectomy patients compared with 35 percent for patients who underwent a radical nephrectomy. In fact, radical nephrectomy was shown to be a significant risk factor for developing chronic kidney disease.
"The results of our study demonstrate that prior to surgery, the baseline kidney function of patients with small kidney tumors was significantly lower than previously recognized," explained Dr. William C. Huang, the study's first author. "Patients who undergo a radical nephrectomy, the most common treatment for small kidney tumors, are at significantly greater risk for the development of chronic kidney disease after surgery compared with those who undergo a partial nephrectomy."
The retrospective study of 662 patients at MSKCC showed that up to 26 percent of the patients had pre-existing chronic kidney disease before undergoing surgery to remove a small tumor (less than 4 cm) from the kidney. In addition, those patients who had the entire kidney removed were more than twice as likely to develop chronic kidney disease.
Although partial nephrectomies account for 30 to 65 percent of all kidney surgeries performed in tertiary care centers in the United States like MSKCC, the latest analysis from the Nationwide Inpatient Sample reported in the journal Urology indicated that 92.5 percent of all kidney cancer surgeries in the United States from 1998 to 2002 were radical nephrectomies. Statistics from the Department of Health in England for the same period reflected a similar trend. In 2002, 96 percent (2,671) of kidney cancer surgeries performed in England were nephrectomies and 4 percent (108) were partial nephrectomies.
"Evidence has accumulated from our Center and elsewhere that partial nephrectomy provides effective local tumor control and equivalent survival rates to that of radical nephrectomy for small tumors," said Dr. Paul Russo, the study's senior author. "However, while approximately 70 percent of kidney tumor operations at MSKCC are partial nephrectomies, national databases from the United States and abroad suggest that greater than 80 percent of patients may be unnecessarily undergoing the more radical surgery to remove the entire kidney, even for small renal tumors. One explanation may be that partial nephrectomy is a more complex surgical procedure."
A number of risk factors for chronic kidney disease, such as diabetes, hypertension, and smoking, are commonly found in patients with kidney tumors, and may account for why the majority of these patients are at risk for developing chronic kidney disease following a radical nephrectomy. Chronic kidney disease can result in the loss of kidney function, sometimes leading to kidney failure. Complications associated with chronic kidney disease include anemia, hypertension, malnutrition, and neuropathy, as well as a reduced quality of life, and even heart disease and death.
"Our study clearly demonstrates, for the first time, the serious effects on kidney function and the high risk of chronic kidney disease when an entire kidney is removed for a small cancer. Chronic kidney disease leads to an increased risk of cardiovascular events, hospitalizations, and even death," said Dr. Peter T. Scardino, Chairman of the Department of Surgery and co-author of the study. "By removing only the cancerous part, we are much more likely to preserve a patient's normal kidney function and avoid the long-term consequences of chronic kidney disease."
Joanne Nicholas | EurekAlert!
How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine
Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
22.01.2018 | Life Sciences
22.01.2018 | Power and Electrical Engineering
22.01.2018 | Power and Electrical Engineering