A study published today in the journal Arthritis Research & Therapy reveals that there is a significant genetic component to the occurrence and severity of bone marrow lesions in the tibia and femur. The study also shows that bone marrow lesions are more common in men and increase with age and weight.
Guangju Zhai, from St Thomas’ Hospital, London, UK and colleagues from institutions in Australia studied 115 siblings from 48 families with a history of osteoarthritis. Zhai et al. used magnetic resonance imaging (MRI) to assess bone marrow lesions in the subjects. The authors then calculated the heritability estimates - or the extent to which they are hereditary - for bone marrow lesions in lateral and medial tibia and femur.
The results of Zhai et al.’s study show that the heritability estimate was 99% for the prevalence of bone marrow lesions in both lateral and medial compartments of the bones. The heritability estimates for the severity of bone marrow lesions are 53% for lateral bones and 65% for medial bones, after adjustment for age, sex, height, weight, muscle strength, knee pain and knee alignment.
The authors conclude that further studies to identify the gene(s) responsible for bone marrow lesions may help in the prevention and management of knee pain in osteoarthritis, the most common form of arthritis.
Juliette Savin | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy