A study published today in the journal Arthritis Research & Therapy reveals that there is a significant genetic component to the occurrence and severity of bone marrow lesions in the tibia and femur. The study also shows that bone marrow lesions are more common in men and increase with age and weight.
Guangju Zhai, from St Thomas’ Hospital, London, UK and colleagues from institutions in Australia studied 115 siblings from 48 families with a history of osteoarthritis. Zhai et al. used magnetic resonance imaging (MRI) to assess bone marrow lesions in the subjects. The authors then calculated the heritability estimates - or the extent to which they are hereditary - for bone marrow lesions in lateral and medial tibia and femur.
The results of Zhai et al.’s study show that the heritability estimate was 99% for the prevalence of bone marrow lesions in both lateral and medial compartments of the bones. The heritability estimates for the severity of bone marrow lesions are 53% for lateral bones and 65% for medial bones, after adjustment for age, sex, height, weight, muscle strength, knee pain and knee alignment.
The authors conclude that further studies to identify the gene(s) responsible for bone marrow lesions may help in the prevention and management of knee pain in osteoarthritis, the most common form of arthritis.
Juliette Savin | alfa
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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