"Three to six weeks after the minimally invasive procedure, kidney function was roughly equal to what is typically achieved with major surgery," said Matthew S. Edwards, M.D., M.S., assistant professor of surgery and lead author. "We hope this will lead to a better way to do angioplasty and stenting by preventing damage to the kidneys and improving kidney function."
The study suggests that the key to success was using suction to prevent the plaque and other material that make up blockages from reaching the kidneys and causing damage. In previous studies of angioplasty without a suction or filtering device, results have been inconsistent.
Angioplasty involves inserting a balloon-like device into the vessel to crush fatty deposits that are blocking blood flow. In many cases, a stent, or scaffold-like device, is inserted to help keep the vessel open. In this study, Edwards used what is called a "distal embolic protection system" that consisted of a balloon system to temporarily block the vessel and a suction system to remove the bits of crushed material that made up the blockage. (Undesirable particles and air bubbles in the blood are known generally as "emboli.")
The study involved 32 patients with a mean age of 70 years. Kidney function improved in 50 percent of the procedures and worsened in none. The narrowed arteries were reopened in 100 percent of cases and mean blood pressure was reduced from 176/81 mm Hg to 158/76 mm Hg.
"These data suggest that distal embolic protection systems may prevent damage to the kidneys during angioplasty and stenting and warrant further investigation," said Edwards.
Surgery to restore blood flow to the kidneys is a common procedure, said Edwards. Previous research at Wake Forest found that about 7 percent of healthy older Americans have renal artery stenosis, or narrowing in the main artery leading to the kidneys, and about 40,000 of the 3.5 million Americans who have the condition will require surgery.
The condition is most common in people with severe, difficult to control high blood pressure. Over time, the hypertension can lead to the narrowed vessels. Conversely, in a small number of cases, it is narrowed vessels to the kidneys that cause hypertension. Surgery may be called for when patients have abnormal kidney function because of reduced blood flow to the organs, or when the uncontrolled hypertension has led to heart failure or blockages in other vessels in the body, such as those leading to the heart.
Without successful surgery to open the kidney vessels and improve organ function, patients have a much greater risk of adverse cardiovascular events, dialysis dependence and death, Edwards said. He plans further studies, in larger groups of patients, of the less invasive procedure for restoring blood flow.
Karen Richardson | EurekAlert!
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Health and Medicine
20.04.2018 | Materials Sciences
20.04.2018 | Earth Sciences