"Three to six weeks after the minimally invasive procedure, kidney function was roughly equal to what is typically achieved with major surgery," said Matthew S. Edwards, M.D., M.S., assistant professor of surgery and lead author. "We hope this will lead to a better way to do angioplasty and stenting by preventing damage to the kidneys and improving kidney function."
The study suggests that the key to success was using suction to prevent the plaque and other material that make up blockages from reaching the kidneys and causing damage. In previous studies of angioplasty without a suction or filtering device, results have been inconsistent.
Angioplasty involves inserting a balloon-like device into the vessel to crush fatty deposits that are blocking blood flow. In many cases, a stent, or scaffold-like device, is inserted to help keep the vessel open. In this study, Edwards used what is called a "distal embolic protection system" that consisted of a balloon system to temporarily block the vessel and a suction system to remove the bits of crushed material that made up the blockage. (Undesirable particles and air bubbles in the blood are known generally as "emboli.")
The study involved 32 patients with a mean age of 70 years. Kidney function improved in 50 percent of the procedures and worsened in none. The narrowed arteries were reopened in 100 percent of cases and mean blood pressure was reduced from 176/81 mm Hg to 158/76 mm Hg.
"These data suggest that distal embolic protection systems may prevent damage to the kidneys during angioplasty and stenting and warrant further investigation," said Edwards.
Surgery to restore blood flow to the kidneys is a common procedure, said Edwards. Previous research at Wake Forest found that about 7 percent of healthy older Americans have renal artery stenosis, or narrowing in the main artery leading to the kidneys, and about 40,000 of the 3.5 million Americans who have the condition will require surgery.
The condition is most common in people with severe, difficult to control high blood pressure. Over time, the hypertension can lead to the narrowed vessels. Conversely, in a small number of cases, it is narrowed vessels to the kidneys that cause hypertension. Surgery may be called for when patients have abnormal kidney function because of reduced blood flow to the organs, or when the uncontrolled hypertension has led to heart failure or blockages in other vessels in the body, such as those leading to the heart.
Without successful surgery to open the kidney vessels and improve organ function, patients have a much greater risk of adverse cardiovascular events, dialysis dependence and death, Edwards said. He plans further studies, in larger groups of patients, of the less invasive procedure for restoring blood flow.
Karen Richardson | EurekAlert!
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
21.02.2017 | Earth Sciences
21.02.2017 | Medical Engineering
21.02.2017 | Trade Fair News