Professor Sukchareon and his team had been studying men with obstructive azoospermia, a condition where sperm are created but cannot be mixed with the ejaculatory fluid due to a physical obstruction (such as a vasectomy). He found that they had high rates of chromosomal aneuploidy (where an abnormal number of specific chromosomes or chromosome sets exist within the nucleus of the cell) and diploidy (containing two sets of chromosomes – unlike most cells in the body, the sex cells should only contain one set of chromosomes.
“The rate of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men”, said Professor Sukchareon. “This raised a lot of questions, so we decided to study the rates of these abnormalities in ejaculated sperm after vasectomy reversal. If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by vasectomy must affect spermatogenesis in the longer term.”
The scientists found a significant correlation between the duration of the obstruction in post vasectomy-reversal men and the number of abnormal sperm, and also between the time interval after vasectomy reversal and the total sex chromosome aneuploidy rate – i.e. the long ago the reversal the better the chances of producing normal sperm.
“This study raises a lot of questions”, said Professor Sukcharoen. “Is the abnormal spermatogenesis reversible, and if so, how long will it take before things get back to normal? Perhaps more importantly, will babies born after vasectomy reversal – either conceived naturally or by ART – have problems themselves?”
To date there have been no studies looking at these questions, he said, and his team are beginning the follow-up research. “We are collecting sperm during vasectomy reversal operations and will compare the aneuploidy rate of these and of the sperm we will collect each month in the future from the same men. This will help us understand what the dangers are. But in the meantime, I think that doctors need to be very aware of the possibility that babies born after vasectomy reversal may have problems.”
Their findings may not affect babies conceived naturally after such a procedure, says Professor Sukchareon, since the female genital tract may select the best sperm for fertilisation. “But this is still uncertain, and until we know more it would probably be safer to freeze ejaculated sperm before vasectomy. We need a lot more evidence and research on this issue before we can be certain of avoiding the dangers.”
Mary Rice | alfa
Scientists develop tiny tooth-mounted sensors that can track what you eat
22.03.2018 | Tufts University
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Trade Fair News
22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences