Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Camelford Resident Died of Rare Form of an Aluminium-Associated Early Onset Alzheimer’s-like Disease

21.04.2006


The first neuropathological examination of a Camelford resident who, in 1988, was exposed to extremely high concentrations of aluminium in drinking water and died of an unknown neurological condition, has revealed a rare form of an early onset Alzheimer’s-like disease.



Analysis of affected brain tissue revealed extremely high concentrations of aluminium - levels similar to those observed previously in aluminium-induced brain diseases, including dialysis-associated encephalopathy (dialysis dementia).

Dr Christopher Exley, of the Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories at Keele University in Staffordshire, and Professor Margaret M Esiri, of the Departments of Clinical Neurology, University of Oxford, and Neuropathology, Oxford Radcliffe NHS Trust, Oxford, found no evidence of genetic mutations normally associated with early-onset forms of Alzheimer’s Disease. The neuropathology was characterised by severe deposition of beta-amyloid in cortical and leptomeningeal blood vessels in the brain.


This is the first discovery of an association between aluminium and any form of presenile dementia and the first time that the aluminium status of an individual has been linked with APOE, the major risk factor in sporadic Alzheimer’s Disease.

It is concluded that there is no likelihood that these levels of aluminium could appear in the brain by chance and, therefore, the previous exposure to aluminium in 1988 may have been a contributing factor. It is recommended that further neuropathological examinations are carried out on similar neurological conditions both from within and without the exposed population of Camelford.

The research is published in the Journal for Neurology, Neurosurgery and Psychiatry and will be available Online First (http://jnnp.bmjjournals.com/onlinefirst.dtl) from Thursday 20th April.

The results of this first neuropathological examination of an individual, who was exposed to the contaminated water in 1988 and has since died, opposes the conclusions of the most recent draft report (January 2005) of a DH Enquiry into Camelford ( http://www.advisorybodies.doh.gov.uk/cotnonfood/lowermoor.htm), which concluded that no long term health effects of the incident were expected. This report, which has been heavily criticised (see for example, http://bmj.bmjjournals.com/cgi/eletters/330/7486/275-a?ck=nck), has yet to be published and would need to be re-written to take the latest findings into account.

Thousands of homes were affected in 1988 when the water supply in Camelford, Cornwall, was contaminated with a toxic mix of aluminium sulphate and metals. A relief driver accidentally tipped 20 tonnes of aluminium sulphate into the wrong tank. The chemicals, used to remove solid particles from cloudy water, went directly into the mains supply at Lowermoor Water Treatment Works and affected up to 20,000 people.

Dr Chris Exley | alfa
Further information:
http://jnnp.bmjjournals.com/onlinefirst.dtl

More articles from Health and Medicine:

nachricht Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>