Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New compound may protect against liver cancer

16.02.2006


Researchers have identified a new compound called CDDO-Im that protects against the development of liver cancer in laboratory animals. The compound appears to stimulate the enzymes that remove toxic substances from the cells, thereby increasing the cells’ resistance to cancer-causing toxins. The National Institute of Environmental Health Sciences and the National Cancer Institute, agencies of the federal National Institutes of Health, provided funding to researchers at the Johns Hopkins Bloomberg School of Public Health for the two-year study.



The compound’s effectiveness at very low doses suggests it may have similar cancer-fighting properties in humans. Researchers believe it may be particularly effective in preventing cancers with a strong inflammatory component, such as liver, colon, prostate and gastric cancers. The compound could eventually play a preventive role in a wide range of other illnesses such as neurodegenerative disease, asthma and emphysema.

The study results are featured on the cover of the February 15, 2006 issue of the journal Cancer Research.


"The results show that the potency of this compound is more than 100 times as great as that of other chemopreventive agents in protecting against cancer," said NIEHS Director David A. Schwartz, M.D. "This protective effect, combined with the compound’s anti-inflammatory properties, make it an exciting avenue for the prevention of other diseases as well."

CDDO-Im belongs to a class of cancer-fighting compounds called triterpenoids. It is a synthetic compound derived from oleanolic acid, a naturally occurring substance found in plants all over the world. Research with other oleanolic derivatives showed marked anti-tumor activity in both animals and humans.

To test the effectiveness of CDDO-Im, researchers treated laboratory rats with either 0.1, 0.3, 1.0, 3.0 or 10 micromole doses of the compound. Two days after treatment with CDDO-Im, the rats were treated with aflatoxin, a naturally occurring toxin that causes liver cancer in animals.

Evaluation of the rat livers showed that the lowest concentration of CDDO-Im led to an 85 percent reduction in pre-cancerous lesions, abnormal growths that have a greater likelihood of developing into actual cancers. "This compound has a much greater effect at a far lower dose than any other compound currently used for preventing aflatoxin-induced cancer in humans," said Thomas Kensler, Ph.D., a cancer biologist with the Johns Hopkins Bloomberg School of Public Health and lead author on the study.

According to Kensler, CDDO-Im activates a protein called Nrf2 that plays a central role in protecting the cells against the toxic effects of environmental agents. "Nrf2 directs certain genes to stimulate the cell’s defense mechanisms," he said. "The protein also stimulates key enzymes that can detoxify harmful agents like aflatoxin and remove them from the cell."

Like other compounds derived from oleanolic acid, CDDO-Im also has strong anti-inflammatory properties that make it ideally suited to the prevention of certain cancers. "When cells become inflamed, they can produce reactive molecules called free radicals that can damage DNA and promote cancer development," said Kensler. "CDDO-Im can also inhibit cancer formation by interfering with this inflammatory process."

Because it can stimulate the body’s cancer-fighting capabilities at such low doses, Kensler believes that CDDO-Im is an excellent candidate for cancer prevention use in humans. "If this compound can produce such a potent and dramatic reduction in the number of pre-cancerous growths, it should have an equally dramatic impact on the development of actual cancers," he said.

In addition to serving as a valuable tool in the development of new cancer prevention interventions, CDDO-Im may offer protection in a wide range of other disease settings. "We know that the Nrf2 protein plays a role in regulating many different kinds of genes involved in protecting the cell from harmful agents," said Kensler. "It follows that activation of the Nrf2 pathway with CDDO-Im could provide protection against a number of diseases where environmental agents play important roles in their causes."

John Peterson | EurekAlert!
Further information:
http://www.niehs.nih.gov
http://www.niehs.nih.gov/home.htm.

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>