Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Preterm birth risk quickly and accurately detected with proteomic profiling

03.02.2006


By profiling specific proteins in amniotic fluid for inflammation, researchers at Yale School of Medicine can quickly and accurately detect potentially dangerous infections in pregnant women, and also predict the possibility of premature birth.



The work will be presented at the 26th Annual Society for Maternal-Fetal Medicine (SMFM) meeting on February 2 by Catalin S. Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology & Reproductive Sciences. Buhimschi and his team will receive a March of Dimes Award for Best Research in Prematurity.

"This is one of the first tests of a proteomic profile in a prospective-blind fashion," said Buhimschi. "One of the key advances in this research is that the test was done using fresh samples of amniotic fluid and not using banked amniotic fluid. This is a multidisciplinary approach that combines the basic science with clinical neonatology."


Mass Restricted (MR) score is a specific proteomic profile used in the study. Presence of the biomarkers indicating inflammation in amniotic fluid can be established in 20 to 30 minutes. This test is much faster than the current method of testing microbiological cultures. If no biomarkers are present, then the pregnancy is uncomplicated.

Buhimschi and his team studied 164 fresh samples of amniotic fluid from 131 patients recruited consecutively with symptoms of premature labor. Proteins in a small sample of amniotic fluid were tested to find a link between the amniotic fluid glucose value, white blood cell count and the outcome of the fetus. An MR sore of three or four is highly predictive of adverse pregnancy outcome.

"We can now detect infections at a much more incipient stage with this proteomic profile," said Buhimschi. "The presence of two biomarkers for inflammation indicates the median time for delivery is four days. If all the biomarkers for inflammation are present, delivery time occurs within hours. Studies to test treatment were not possible before. We now have to take it into the clinic and use the results of this test to provide a rapid treatment to the mother and its baby. This platform is also available to help diagnose other diseases."

In addition to this abstract, Yale University has the most presentations at SMFM supported using funds obtained via extramural NIH mechanisms.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>