Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mice give skin cancer clue

25.09.2001


Mice work says keep kids safe from the sun.
© Photodisc


Mouse studies emphasize children’s cancer risk from sunburn.

Serious sunburn in childhood may raise the risk of developing the deadliest form of skin cancer as an adult, research in mice suggests1. The experiments could lead to a better understanding of malignant melanoma and of how and when to protect ourselves from the sun.

"I have my kids wear hats and put sunscreen on like crazy now," says the study’s leader Glenn Merlino, of the National Cancer Institute in Bethesda, Maryland. The differences between mice and human skin mean that caution is needed in interpreting the results, he says, but they still hold lessons for parents.



Merlino’s team has engineered mice with "the closest thing we see to human skin", he says. Melanocytes, the pigment-producing cells that become cancerous in melanoma, are spread through the rodents’ skin as they are in humans. Normal mouse skin is quite different.

Mice given a sunburn-inducing dose of ultraviolet light at 3.5 days of age began to develop melanomas at around 6 months old. By a year of age, about half of these mice had cancer. Six-week-old mice given the same amount of ultraviolet light did not develop tumours.

The human equivalents of these mouse ages is not yet clear. The team aims to study exposure over a wider range of times to work out when young humans may be most at risk from sunburn.

The dangers of childhood sunburn are well known, says dermatologist Rona Mackie of the University of Glasgow, UK. "We’ve preached for years that young children are particularly vulnerable," she says. The age-related association between sunburn and melanoma contrasts with other forms of skin cancer, in which the risk rises more steadily with overall exposure to the sun.

Mackie believes this mouse model may help discover how ultraviolet light leads to cancer. Sunburn could turn melanocytes cancerous directly, or it might render the immune system unable to destroy cancer cells when they appear later, she says.

Such an understanding might yield therapies for repairing sunburn damage, Mackie adds.

References

  1. Noonan, F. P. et al. Neonatal sunburn and melanoma in mice. Nature, 413, 271 - 272, (2001).


JOHN WHITFIELD | Nature News Service
Further information:
http://www.nature.com/nsu/010920/010920-10.html

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>