Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mice give skin cancer clue

25.09.2001


Mice work says keep kids safe from the sun.
© Photodisc


Mouse studies emphasize children’s cancer risk from sunburn.

Serious sunburn in childhood may raise the risk of developing the deadliest form of skin cancer as an adult, research in mice suggests1. The experiments could lead to a better understanding of malignant melanoma and of how and when to protect ourselves from the sun.

"I have my kids wear hats and put sunscreen on like crazy now," says the study’s leader Glenn Merlino, of the National Cancer Institute in Bethesda, Maryland. The differences between mice and human skin mean that caution is needed in interpreting the results, he says, but they still hold lessons for parents.



Merlino’s team has engineered mice with "the closest thing we see to human skin", he says. Melanocytes, the pigment-producing cells that become cancerous in melanoma, are spread through the rodents’ skin as they are in humans. Normal mouse skin is quite different.

Mice given a sunburn-inducing dose of ultraviolet light at 3.5 days of age began to develop melanomas at around 6 months old. By a year of age, about half of these mice had cancer. Six-week-old mice given the same amount of ultraviolet light did not develop tumours.

The human equivalents of these mouse ages is not yet clear. The team aims to study exposure over a wider range of times to work out when young humans may be most at risk from sunburn.

The dangers of childhood sunburn are well known, says dermatologist Rona Mackie of the University of Glasgow, UK. "We’ve preached for years that young children are particularly vulnerable," she says. The age-related association between sunburn and melanoma contrasts with other forms of skin cancer, in which the risk rises more steadily with overall exposure to the sun.

Mackie believes this mouse model may help discover how ultraviolet light leads to cancer. Sunburn could turn melanocytes cancerous directly, or it might render the immune system unable to destroy cancer cells when they appear later, she says.

Such an understanding might yield therapies for repairing sunburn damage, Mackie adds.

References

  1. Noonan, F. P. et al. Neonatal sunburn and melanoma in mice. Nature, 413, 271 - 272, (2001).


JOHN WHITFIELD | Nature News Service
Further information:
http://www.nature.com/nsu/010920/010920-10.html

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

How to merge two black holes in a simple way

26.09.2016 | Physics and Astronomy

Australian technology installed on world’s largest single-dish radio telescope

26.09.2016 | Physics and Astronomy

New mechanisms uncovered explaining frost tolerance in plants

26.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>