A virus that exploits a gene defect common to cancer cells and selectively kills them may offer a new avenue for therapy, suggest researchers in Nature.
The gene p53 is mutated in about half of all human cancers (an event directly implicated in tumour progression) so a way of killing such cells offers the attractive possibility of treating multiple cancer types with one drug. The human adeno-associated virus (AAV) selectively induces cell death in p53-defective cells, Peter Beard and his colleagues of the Swiss Institute for Cancer Research (ISREC) in Epalinges, Switzerland, have now discovered. Cells retaining their copy of p53 instead halt cell division.
Even AAVs engineered to lack all genes and containing only hairpin-looped DNA ends cause cell death, suggesting that the viral DNA structure mimics DNA damage in the cell. Cells have very sensitive sensors for DNA damage that can activate repair mechanisms or drive them to suicide to prevent mutation accumulation and hence potential oncogenic transformation. Tumours in mice were also reduced by injection of the virus, the team found.
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
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20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences