Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood flow to brain may be clue to certain dementias

31.08.2005


The amount of blood flowing into the brain may play a larger role in the development of dementia than previously believed, according to a study in the September issue of the journal Radiology.



Researchers from Leiden University Medical Center in the Netherlands used magnetic resonance imaging (MRI) to examine the brains of elderly patients with and without dementia related to Alzheimer’s or Parkinson’s disease. As expected, MR images showed that the patients with late-onset dementia had more brain damage compared with young adults and with seniors who had optimal cognitive function. But researchers found that the late-onset dementia group also had a much lower rate of blood flow to the brain than the other two groups.

"Our findings not only support the hypothesis that vascular factors contribute to dementia in the elderly, they are highly suggestive that a diminished cerebral blood flow indeed causes brain damage," said Aart Spilt, M.D., a Leiden radiology resident and lead author of the study. "This gives us a clue to the genesis of dementia."


Dementia is a loss of cognitive functions, such as thinking, remembering and reasoning, that interferes with normal activities. Although many conditions can produce these symptoms, Alzheimer’s disease is the most common cause of dementia. Some patients with Parkinson’s disease also develop dementia.

In the Dutch study, researchers examined 17 patients with late-onset dementia (dementia occurring after age 75), another 16 seniors of the same age with optimal cognitive function and 15 healthy younger individuals. Researchers used MRI to measure cerebral blood flow and the extent of structural brain damage in each person and then compared the results of the three groups.

Average total cerebral blood flow in the healthy young individuals was 742 milliliters (mL) per minute. Cerebral blood flow in the two elderly groups averaged 496 mL per minute, or 246 mL per minute lower than the younger group. In patients with dementia, average cerebral blood flow was 443 mL per minute, or 108 mL per minute lower than seniors of the same age with optimal cognitive function (551 mL per minute).

Although patients with dementia have been shown to require less cerebral blood flow as the brain becomes less active, Dr. Spilt’s research provides some evidence that the decreased blood flow may lead to some types of dementia.

"The findings emphasize the importance of monitoring both high and low blood pressure in older adults," Dr. Spilt said. "Possible causes of low cerebral blood flow include heart failure and a narrowing of cerebral or cervical arteries."

Maureen Morley | EurekAlert!
Further information:
http://www.rsna.org

More articles from Health and Medicine:

nachricht Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern

nachricht New vaccine production could improve flu shot accuracy
25.07.2017 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Serious children’s infections also spreading in Switzerland

26.07.2017 | Health and Medicine

Biomarkers for identifying Tumor Aggressiveness

26.07.2017 | Life Sciences

NASA mission surfs through waves in space to understand space weather

25.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>