Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue recreated with balls of gelatin

31.08.2005


Repairing major damage to the derma is a difficult problem facing plastic surgeons. But now researchers at Linköping University have hit upon a highly promising method. By injecting tiny balls of gelatin, they have managed to get various types of cells to grow spontaneously in the areas where new tissue needs to be generated.



Instead of moving skin from other parts of the body or operating in prostheses of non-biological material, it is becoming more and more common for plastic surgeons to cultivate the patient’s own cells to make repairs. In burn injuries, for example, derma cells are cultivated from epithelium cells and then grow onto the surface of the wound.

But to go deeper, other methods are called for. The research team at Linköping University has studied various ways to cultivate the cell type needed in a matrix, a “scaffolding,” and then to apply it to the body. The best results were attained using porous spheres of micro format (a few hundredths of a millimeter in diameter) consisting of gelatin­-a substance that occurs naturally in the human body. (Images are available)


“These spheres offer multiple advantages. Enormous numbers of cells can be cultivated in the gelatin, and the material can also be injected in the patient,” says Fredrik Huss, a plastic surgeon in training who describes the method in his doctoral dissertation to be defended on September 2.

All types of cells attempted grew extremely well in the gelatin balls: skin cells, connecting tissue cells, cartilage cells, early stages of fat cells, and mammary gland cells. Experiments with transplanting in mice also yielded favorable results. Injection under the skin of spheres containing connecting tissue cells and fat cells led to good regeneration of tissue. But it is not even necessary to cultivate the cells in advance. Empty balls were injected into the upper arm of healthy volunteers. For comparison, saline solution and Resylane, a commonly used anti-wrinkle substance, were injected. The result was excellent regeneration of tissue inside the spheres, which were then degraded and disappeared, and there were no signs of rejection. On the other hand, Restylane injection produced no new generation of tissue.

“Our findings open up tremendous potential for the repair of soft body parts. It is a simpler and more dependable method than the fat transplants carried out today,” says Fredrik Huss, who, together with Elof Eriksson, is participating in an international research conference on tissue engineering TERM 2005, arranged by Linköping University. For the program, see http://www.liu.se/forskning/filer/program-term2.pdf.

Åke Hjelm | alfa
Further information:
http://www.liu.se

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>