Research published by the University of Helsinki, Finland, indicates that cytostatic and radiation therapies administered before stem cell transplantation often damage children’s permanent teeth.
Detrimental effects of cytostatic and radiation therapies on dental development have been known for a long time, but knowledge about the dental consequences of high-dose anticancer therapy preceding stem cell transplantation has so far been scarce. Päivi Hölttä, Licentiate in Dentistry, from the Institute of Dentistry, University of Helsinki, has studied the effects of high-dose anticancer chemotherapy and total body irradiation on the development of permanent teeth.
Tooth development is a genetically controlled chain of events that can be disturbed by various environmental factors. The development of permanent teeth begins as early as the 20th week of gestation and continues until the age of 14 to 15 years with the exception of wisdom teeth, which still continue their development for several years. All this time teeth are vulnerable to developmental aberrations.
Paivi Lehtinen | alfa
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