Inhibitory systems are essential for controlling the pattern of activity in the cortex, which has important implications for the mechanisms of cortical operation, according to a Yale School of Medicine study in Neuron.
The findings demonstrate the inhibitory network is central to controlling not only the amplitude, extent and duration of activation of recurrent excitatory cortical networks, but also the precise timing of action potentials, and, thus, network synchronization, said David McCormick, professor of neurobiology and senior author of the study.
There are two cell types in the cortex, excitatory and inhibitory. The cortex has a tendency to make recurrent excitation, and, if not properly controlled by the inhibitory system, this could lead to seizures, as is seen in epilepsy.
Jacqueline Weaver | EurekAlert!
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