Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First detailed picture of migraine attack

22.08.2005


Every eight adults in Sweden suffer from migraine. Using a new method, researchers at Göteborg have managed for the first time ever to provide a detailed picture of an untreated attack. This will be of great significance for the development of new forms of treatment. The findings are reported in a dissertation at the Sahgrenska Academy.



In the first nation-wide study of migraine in Sweden, it is shown that one million individuals, more than 13 percent of the adult population, suffer from migraine. In total they experience some ten million attacks each year. The condition is characterized by an intensive pulsing headache, hypersensitivity to light and sound, and severe nausea and vomiting. Migraine is roughly twice as common among Swedish women as Swedish men. About 200,000 Swedes have migraine without being aware that their symptoms are classified as such. A majority of those affected report negative impact on the highest ranking factors in life, such as family life and the ability to perform their work and enjoy meaningful leisure time.

Only every fourth individual with migraine is seeing a doctor, which is a lower figure than for the rest of the western world. The study shows moreover that every third individual who has seen a doctor regards the information about various treatment options as poor or extremely poor.


"Many people had gone to their doctor previously but stopped. This is remarkable considering the fact that most people want to try another migraine treatment than their current one," says Mattias Linde, a medical specialist in neurology and author of the dissertation.

In his dissertation Mattias Linde has managed to use a new method to capture detailed pictures of migraine attacks. A number of patients who could stand to refrain from any treatment for 72 hours were asked to assess the intensity of the various migraine symptoms on a hundred-degree scale. In this way he was able for the first time to produce a highly exact picture of how a migraine attack develops hour by hour.

"This is a breakthrough that provides research with a new and unique picture of the great complexity and wealth of variation that characterizes this enigmatic condition. The pain tends to follow a slowly undulating rhythm between medium and insufferable intensity," says Mattias Linde.

The findings show that acute drugs often provide good but short-lived relief, whereupon the complaints return to their original pattern after a couple of hours. The conclusion is that the various symptoms are driven by a common factor in the brain, and that modern treatments for attacks fail to block off this unknown area.

The overwhelmingly dominant thinking among migraine researchers internationally, and not least in the U.S., is that a condition for effective treatment is that it must be ingested early in the course of an attack before the pain mounts. This has now been refuted by Mattias Linde, who has compared early and late injection treatment in the same patients. No statistically significant difference was shown, and a majority of the patients felt that the treatment was equally effective when administered late, during high levels of pain.

"It’s reassuring now to be able to encourage patients to take their treatment, either as a nasal spray or as a suppository, even if they didn?t do so at an early stage," says Mattias Linde.

Many patients experience side effects of modern treatments for attacks in the form of unpleasant and sometime painful sensations. For example, it can be painful to come into contact with water, which often leads to a concern that patients will avoid taking their medicine. The dissertation shows that this is a benign and short-lived phenomenon resulting from a lowering of the pain threshold in the nervous system.

Press Office | alfa
Further information:
http://www.vr.se

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>