Metastasis is the primary cause of deaths in cancers. Published in the September 1 issue of G&D, Dr. Tak Mak and colleagues have successfully generated a strain of RhoC-deficient mice, providing long-awaited in vivo confirmation of RhoCs critical role in tumor metastasis.
They found that RhoC, a Ras-related GTPase, is dispensable for embryonic development and tumor initiation, but is essential for metastasis. RhoC-deficient mice do not display gross phenotypical abnormalities or differences in the rate of induced tumorigenic potential, but RhoC-deficient mice do display markedly less tumor metastasis, compared to their wild-type littermates.
Preliminary results suggest that in RhoC deficient mice, the tumor cells have less motility (thus reduce the probability of cancer cells escaping from the primary tumors) as well as having reduced survival properties when they have spread to secondary sites and organs. Further research is underway to determine more clearly the mechanism of RhoC-induced metastasis.
Heather Cosel | EurekAlert!
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Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
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