Metastasis is the primary cause of deaths in cancers. Published in the September 1 issue of G&D, Dr. Tak Mak and colleagues have successfully generated a strain of RhoC-deficient mice, providing long-awaited in vivo confirmation of RhoCs critical role in tumor metastasis.
They found that RhoC, a Ras-related GTPase, is dispensable for embryonic development and tumor initiation, but is essential for metastasis. RhoC-deficient mice do not display gross phenotypical abnormalities or differences in the rate of induced tumorigenic potential, but RhoC-deficient mice do display markedly less tumor metastasis, compared to their wild-type littermates.
Preliminary results suggest that in RhoC deficient mice, the tumor cells have less motility (thus reduce the probability of cancer cells escaping from the primary tumors) as well as having reduced survival properties when they have spread to secondary sites and organs. Further research is underway to determine more clearly the mechanism of RhoC-induced metastasis.
Heather Cosel | EurekAlert!
Finnish research group discovers a new immune system regulator
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Minimising risks of transplants
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy