Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New guidelines: Common drugs can calm essential tremor

27.06.2005


Imagine not being able to hold a glass, tie your shoelaces or write a check. For people with the common movement disorder known as essential tremor, simple tasks requiring fine motor coordination become increasingly difficult, sometimes even impossible. Three times more prevalent than Parkinson’s disease, essential tremor involves uncontrollable shaking of the hands, arms, head or voice. The largely hereditary neurological condition can begin in early adulthood and worsen with age.



In an effort to help physicians and patients best cope with essential tremor, the American Academy of Neurology has released the first guidelines for its treatment. The report, posted online, will be published in the June 28 issue of the journal Neurology.

Specific drugs commonly used to treat high blood pressure and seizures can be beneficial in the treatment of essential tremor, according to the guidelines. For limb tremors, surgery can be an option if drug therapy is ineffective.


"Essential tremor can be quite debilitating and cause embarrassment in social situations. For instance, in a restaurant the person may have difficulty eating when they try to pick up a fork or spoon and bring food to their mouths," said lead guideline author Theresa Zesiewicz, MD, an associate professor of neurology at the University of South Florida (USF)College of Medicine. "Though the tremors do not completely disappear with treatment, they can be managed, making a huge difference in the daily lives of people with essential tremor."

The guideline panel reviewed 211 articles to make evidence-based recommendations on the treatment of essential tremor.

Propranolol, long-acting (LA) propranolol, and primidone were each found to significantly reduce limb tremors and were strongly recommended in the guidelines. Propranolol is also used to treat high blood pressure. Primidone is an anti-seizure medication. Propranolol and primidone may be used in combination for limb tremor when either drug is insufficient alone. Propranolol was also recommended for head tremors, although not as strongly as it was recommended for limb tremors.

The panel also found supporting evidence for other medications to be considered for limb tremors. Sotalol or atenolol – drugs used to regulate blood pressure – can be used as alternatives to propranolol and primidone. The anti-seizure drugs gabapentin (as monotherapy) and topiramate were also recommended.

The panel found modest evidence to recommend injections of botulinum toxin A for limb, head, or voice tremors.

Surgery can be recommended if drug therapy is ineffective for limb tremors. Deep brain stimulation was found to have fewer severe complications than thalamotomy, according to the guideline. In deep brain stimulation, an electric probe is placed inside the thalamus which helps block the impulses that cause tremors. A thalamotomy places a lesion on a small part of the thalamus, which helps stop the signals that cause tremors.

"Both surgeries were more effective than medications at improving the tremors, reducing their magnitude by as much as 60 to 90 percent, compared to 50 percent or less for medications," Dr. Zesiewicz said. "However, patients who underwent surgery experienced more adverse side effects, so the procedures are only recommended for those who do not respond to medications."

The panel found insufficient evidence to recommend deep brain stimulation to treat head or voice tremor.

Anne DeLotto Baier | EurekAlert!
Further information:
http://www.hsc.usf.edu
http://www.aan.com

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>