Oral rinse predictor of marrow transplant effectiveness
Indicates whether infection will develop
Simple analysis of a bone marrow transplant patients oral rinse can give medical personnel a quick indication of the transplants effectiveness and predict whether an infection will develop, says a University of Toronto researcher. Dr. Michael Glogauer, a U of T dentistry professor with the CIHR Group in Matrix Dynamics, Dr. Yigal Dror, a professor at the U of T Faculty of Medicine and a hematologist at the Hospital for Sick Children, and dentistry doctoral candidate Chrissy Cheretakis conducted the study, which received advance online publication this month in Bone Marrow Transplantation. "This test is telling you something you cant yet see in a blood test," says Glogauer, "and we obtained the information simply by having patients rinse their mouths, which is something theyd be doing anyway to counteract the oral mucositis caused by their treatment regimen."
The researchers monitored the oral rinses of 29 pediatric bone marrow transplant patients, testing the basic sodium bicarbonate solutions for the return of neutrophils, specialized white blood cells which fight infection. Their test was able to detect the white blood cells about a week earlier than the blood test which is commonly used to confirm a successful bone marrow transplant.
The gap between the time their test showed the presence of white blood cells in the mouth and the time the cells appeared in a blood test also indicated those patients who would likely be prone to infection during their recovery. A difference of less than four days was an excellent indicator of patients who were susceptible to infection, Glogauer says.
"It shows promise as a non-invasive way to track a patients recovery," he says. "We are using mice to study the underlying mechanisms at work here to help us better understand white blood cell recovery and function during bone marrow transplant therapy."
"Dr. Glogauers work is an excellent example of the way in which research is unravelling the complex relationship between oral health and systemic conditions," says Dr. Cy Frank, Scientific Director of CIHRs Institute of Musculoskeletal Health and Arthritis. "We applaud Dr. Glogauer and his colleagues for the creation of new knowledge that will greatly benefit patients requiring bone marrow transplants."
The researchers are now experimenting with ways to make the test applicable at the bedside by developing a reaction that will cause the rinse to turn colour when the presence of white blood cells is detected.
Dr. Michael Glogauer | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...