Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early origins of obesity: programming the appetite regulatory system

13.05.2005


An article in The Journal of Physiology presents important research showing that events before birth can permanently change patterns of appetite and fat deposition in child and adult life.



A collaborative effort headed by Prof I. C. McMillen, of the Centre for the Early Origins of Adult Health at the University of Adelaide, Australia, and Dr C. L. Adam of The Energy Balance and Obesity Division of the Rowett Research Institute, Aberdeen, is shedding new light on potential causes of child and adult obesity. This research forms part of an exciting new area of physiology, the early origins of adult disease, which is beginning to unravel some of the mechanisms by which events which occur during the development of an individual can permanently affect postnatal physiology.

This paper reviews evidence from a series of studies which have shown that there are robust associations between the prenatal experience and patterns of fat deposition and appetite regulation in postnatal life. Both epidemiological studies across large sectors of human populations in a large number of countries, and animal models in which the prenatal environment has been artificially manipulated, have shown that prenatal exposure to either an increased or decreased levels of nutrition before birth leads to an increased risk of obesity in postnatal life.


Building on the strong foundation of studies linking prenatal exposures to patterns of postnatal feeding behavior, these researchers have addressed the question, to what extent the fetus has a functional capacity for regulating its appetite. Dr McMillen and Dr Adam have been the first to demonstrate that the fetus possesses all the components of the appetite-regulating system before birth, and that increases in nutritional supply are able to regulate the expression of these components.

An up and coming researcher in this field and coauthor, Beverly Mühlhäusler, says: “The concept of a fetal appetite is a difficult and intriguing one. What our research suggests is that all the components of the system which we know regulates appetite in postnatal life are already there before birth and may be responding to signals of nutritional status. This, of course, raises the possibility that changes in the fetal environment can permanently change the way that this system develops and result in changes in feeding behaviour after the individual is born.”

With child and adult obesity currently at epidemic proportions in both the developed and developing world, this research offers new and important insights into the causes of this complex disease.

Lucy Mansfield | alfa
Further information:
http://www.blackwell-synergy.com

More articles from Health and Medicine:

nachricht The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo

nachricht Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>