Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Add an ’E’ to the alphabet for identifying melanoma

08.12.2004


One more letter should be added to the alphabetic list of warning signs of melanoma, a potentially deadly skin cancer, according to a group of NYU School of Medicine dermatologists and their Australian colleagues. Based on a review of the medical literature, they recommend adding the letter "E" -- for "evolving" -- to the first four letters of the alphabet that are already used widely to help physicians and adults identify suspicious moles on the skin.



Their report is published in the Dec. 8, 2004, issue of the Journal of the American Medical Association (JAMA).

Almost 20 years ago, a group of NYU dermatologists introduced the ABCD acronym for recognizing growths on the skin that could be early melanomas. They devised the rule based on many years of clinical experience, which taught them that early melanomas can be identified by their asymmetry, uneven borders, colors, and size.


The warning signs are: "A" for asymmetry; one half of a mole doesn’t match the other half; "B" for border irregularity; the edges of a mole are ragged, notched or blurred; "C" for color; a non-uniform mixture of brown, black, red, white, or blue; and "D" for diameter greater than 6 millimeters, the size of a pencil eraser.

The ABCD rule has been helpful in identifying early melanoma. But now the original group of NYU dermatologists who devised the rule, along with some of their younger colleagues, recommends expanding the rule to recognize that early melanomas frequently change in appearance. This is especially true for a type of melanoma called nodular that doesn’t fit neatly into the ABCD criteria, explains David Polsky, M.D., Ph.D., a dermatologist and one of the authors of the new report. Dr. Polsky is Associate Director of the NYU Department of Dermatology’s Pigmented Lesions Section.

Nodular melanoma accounts for 10 to 15 percent of all melanomas. One of four basic types of melanomas, the nodular form is the most aggressive. But it frequently doesn’t look suspicious, notes Dr. Polsky, because it may not have the ABC features of early melanomas. However, there are many reports in the medical literature that highlight the changing nature of these lesions, which is the most important clue to their diagnosis.

In a study of 125 patients cited in the JAMA report, for example, 78 percent of patients with nodular melanoma noted some kind of a change in the appearance of their lesion. Patients with other forms of melanoma in the study also noted a change the appearance of their lesion. Moreover, in another cited study of 169 pigmented lesions, dermatologists noted that the lesions that had changed were at least four times more likely to be melanoma than the lesions that did not change.

"An evolving lesion is one which is changing in terms of the five S’s -- size, shape, symptoms such as itching or tenderness, surface bleeding, or shades of color," says Dr. Polsky. "Essentially, a lesion that significantly changes is a concerning lesion."

The incidence of melanoma continues to rise. This year it is expected to strike 55,100 people in the United States, and some 7,910 people with the disease are expected to die, according to the American Cancer Society. Excessive exposure to sunlight, a fair complexion, a family history of melanoma, and numerous moles, among other factors, place people at higher risk for developing the disease. With early detection and prompt treatment, however, melanoma is highly curable.

Jennifer Berman | EurekAlert!
Further information:
http://www.med.nyu.edu

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>