Benefits of weight loss may depend on alignment of affected leg, study suggests
A painful and sometimes crippling disease characterized by progressive cartilage loss, osteoarthritis (OA) of the knee affects an estimated 6 percent of adults over age 30. AT present, no treatments are available that have been shown to impede the destructive course of this disease, apart from knee replacement surgery. Numerous studies have shown that being overweight increases the risk of developing knee OA, whose sufferers, on average, tend to be heavy. While doctors routinely advise patients to lose weight, researchers have yet to affirm the benefits of weight loss to prevent ongoing joint deterioration.
To better understand the effect of body weight on the course of knee OA, researchers at Boston University focused on an important predictor of disease progression: limb malalignment, defined by joint space loss at the point where the thigh and shin bones connect to the knee. Featured in the December 2004 issue of Arthritis & Rheumatism, their findings suggest that the benefits of weight loss for knee OA patients depend on the degree of alignment in the affected leg.
Amy Molnar | EurekAlert!
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Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
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A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
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