Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Canadian researchers to develop ’smart drug’ to repair psychiatric disorders

29.11.2004


“Smart” drugs capable of targeting specific brain cells to control psychiatric disorders such as autism and schizophrenia may be ready for early clinical trials within three years, with the launch of a $1.5 million project to take place at the Brain Research Centre (BRC), a partnership of the University of British Columbia and Vancouver Coastal Health Research Institute (VCHRI).



The new drugs would be the first significant change in decades to medications used to treat psychiatric disorders, says neuroscientist and team leader Yu Tian Wang, a UBC professor of Medicine and BRC member.

“We’re designing a whole new generation of medications that will work only on brain cells in areas that need to be repaired,” says Wang. “This new type of drug will correct abnormal brain functions in a targeted way, so patients don’t experience the side effects found in existing medications that affect the whole brain.”


One of only three investigations funded in NeuroScience Canada’s new Brain Repair Program, the project brings together five researchers from across Canada, including three investigators from the BRC at UBC Hospital.

Healthy brain functioning relies on a balance between the chemical messengers that stimulate brain cell activity (excitatory neurotransmitters) and those that diminish activity (inhibitory neurotransmitters.)

When balance is disrupted, the flow of information among brain cells in certain areas becomes confused. The result is impairments in perception, thought and behaviour seen in patients with brain disorders ranging from autism to major psychoses including schizophrenia and depression.

Using sophisticated equipment to view, study and manipulate brain messaging at the cellular level, the team will test their design of a type of drug that can fine-tune communication between brain cells and bring excitatory and inhibitory activity into a healthy balance.

Existing anti-psychotic drugs adjust communication on cell surfaces throughout the brain. Balance is restored in affected areas, however, the drugs may cause imbalance in normal, unaffected areas, leading to negative side effects. Side effects can range from sluggishness, insomnia and anxiety to severe psychoses, and limit prolonged use of these medications.

The new generation of “smart” drugs will target only the cells where communication balance is impaired, leaving healthy areas of the brain unaffected.

Wang estimates the new type of drug could be available to patients within five to 10 years.

Brain and nervous system disorders affect one in five Canadians and are among the leading causes of death in this country and are the leading cause of disability. Health Canada has estimated the economic burden of these disorders at $22.7 billion and costs are expected to rise significantly as the population ages.

Other team members are: (in alphabetical order) Assistant Prof. Alaa El-Husseini, UBC Dept. of Psychiatry and BRC; Associate Prof. Stephen Ferguson, University of Western Ontario; Assistant Prof. Ridha Joober, McGill University; Professor Anthony Phillips, UBC Dept. of Psychiatry and BRC.

Hilary Thomson | EurekAlert!
Further information:
http://www.ubc.ca
http://www.neurosciencecanada.ca.

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>