A team of Danish researchers have discovered that by blocking a specific enzyme, it is possible to check the spread of cancer in the body. This finding may be the first step towards preventing deaths due to cancer spreading to other parts of the body. The discovery may also help reduce the amount of chemotherapy used.
The discovery, which was recently published in the prestigious International Journal of Cancer, was made by a research team from the Finsen Laboratory at Copenhagen University Hospital – Rigshospitalet and the Institute of Molecular Biology at the University of Copenhagen. “What is special about the enzyme – urokinase plasminogen activator (uPA) – is that the cancer needs the enzyme in order to spread throughout the body, but the body does not need the enzyme to function normally. This means that we should be able to block the enzyme and thereby check the spread of the cancer without causing the strong side effects for the patients that we see with other forms of therapy today,” says Morten Johnsen, Institute of Molecular Biology, University of Copenhagen.
“When women discover a lump in their breast, it can be removed. But if the cancer has spread to other parts of the body, such as the lungs, then it can become life-threatening. So we’ve come a long way towards being able to limit the spread of the cancer in the body,” says Kasper Almholt, PhD, Finsen Laboratory.
Associate Prof. Morten Johnsen | alfa
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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