Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early disclosure: post-operative radiotherapy improves progression-free survival in prostate cancer

26.10.2004


Immediate post-operative radiotherapy following surgery to remove the prostate results in improved progression-free survival for prostate cancer patients, according to the results of a study presented here today (Tuesday 26th October 2004) by Prof Michel Bolla of CHU de Grenoble, Grenoble, France, at the 23rd Meeting of the European Society for Therapeutic Radiation and Oncology.



Prostate cancer is the most common cancer in men, but if it is detected early enough by individual (or mass) screening, the likelihood of cure is high. Surgical removal of the prostate (prostatectomy) is one of the standard treatments for localised prostate cancer. From 1992 onwards, radical prostatectomy was more frequently used for patients with early stage prostate cancer (e.g. those whose tumour is clinically inapparent / is found incidentally or where the tumour is palpable but confined within the prostate gland itself).

This randomised clinical trial investigated the effect of radiotherapy given within four months after prostatectomy versus a wait-and-see policy, following radical prostatectomy. Trial participants had no lymph node involvement and no metastatic disease but all displayed high risk factors for local disease recurrence (e.g. capsule perforation, positive margins or involvement of seminal vesicles). The trial ran from 1992 - 2001 and, following review by an independent data monitoring committee in December 2003 (with a median follow-up of 5 years), early disclosure of the trial results was recommended. These are the efficacy results from this trial.


Of the study group (1,005 patients), 503 men received 60Gy conventional external beam radiotherapy delivered over 6 weeks following radical prostatectomy, while the remaining 502 men received no radiotherapy following radical prostatectomy. The outcome was first measured by assessing the biological progression-free survival measured by the level of prostate specific antigen (PSA) in the blood (time to twice confirmed PSA* increase over basal levels, or first clinical failure, or death). Biological progression-free survival at 5 years was 72.2% in patients who had received radiotherapy and 51.8% in patients who had prostatectomy alone. This demonstrates a clear benefit in terms of biological progression-free survival for men who received radiotherapy treatment in addition to surgery.

Clinical progression-free survival (i.e. where the disease has not spread to other sites, or where no tumour is detectable by endo-rectal examination) was improved from 74.8% to 83.3% at 5 years in men who received radiotherapy. These data show a statistically significant improvement in clinical progression-free survival for men who received immediate post-operative radiotherapy.

The incidence of local disease recurrence was also significantly decreased following radiotherapy. Grade 3 side effects were found to occur in less than 5% of patients in both groups making post-operative irradiation suitable for all patients. Long-term follow up of the trial patients will allow clinicians to more accurately predict the long-term benefits of immediate post-operative radiotherapy in this setting.

“Based on these results I would recommend that all men with high risk of local failure after prostatectomy should be considered for immediate post-operative radiotherapy”, said Prof Bolla. “This approach has clear benefits that outweigh the risk of side effects which occur in a small proportion of men”.

Stuart Bell | alfa
Further information:
http://www.fecs.be

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>