Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New gel pill could mean an end to injections

20.09.2004


Scientists in India have developed a new gel that is taken orally and is capable of delivering drugs to manage diseases often requiring an injection. The research, published in the journal Polymer International, suggests the gel could offer a painless way of treating diabetes, ulcerative colitis, Crohn’s disease, bowel cancer, constipation and some infections, all of which require local drug delivery.



In these conditions, oral administration of medication cannot be achieved easily because highly acidic gastric fluid in the stomach contain enzymes that can break down the active drug before it reaches the target site. But Dr Sunil Bajpai and Ms Seema Dubey from the Polymer Research Laboratory at Government Model Science College in Jabalpur, India, produced a polymer gel into which a drug may be simply loaded.

‘Intelligent materials’


The hydrogel system has been designed so that when swallowed by the patient, it passes through the stomach retaining the majority of the drug by protecting it from the stomach acids. 56 % of the drug is released where it is needed - further down the gastrointestinal tract in the colon. It is deposited when the gel swells in response to the colon’s (high) alkaline pH.

“The terpolymeric hydrogel system studied by our team provides an alternative to the parenteral medication of insulin. It is now necessary to carry out in vivo studies of this hydrogel system so that it could be further modified to produce oral delivery pills,” says Bajpai.

In the body

To test the gel, the scientists put vitamin B2 in the hydrogel in place of a drug and studied its releasing capacity in conditions simulating a human body, namely gastric (pH 1.0) and intestinal (pH 7.4) fluids at a body temperature of 37oC, under various experimental conditions. This helped to predict the behaviour of the vitamin-loaded gel in body conditions.

Problems caused by other medication, such as sudden increase and subsequent rapid decrease of blood serum concentration, which sometimes reaches a toxic and ineffective level, can be prevented using the new gel, which gives targeted, controlled release of the drug. “This is important in a number of diseases and medical conditions. The new material developed in this research is simple, elegant, versatile, and performs well,” says Dr Malcolm Purbrick, Industrial Polymer Science Editor of Polymer International.

Lizzy Ray | alfa
Further information:
http://interscience.wiley.com/polymerinternational
http://www.soci.org

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>