Rhabdomyosarcoma is a highly malignant aggressive form of soft tissue cancer in children, the causes of which are currently unknown. Although the fibrous growths can be found all over the body they commonly develop around the head, neck, bladder and testes in young boys. The most common age for onset is between 1-5 years of age. The treatments used are usually chemotherapy using a combination of drugs, radiotherapy and surgery and although quite effective (66% success rate at present), the side affects commonly experienced by the young patients are very unpleasant and the whole process can prove to be very traumatic not only for the patient but for the families too. So there is a need for a better way of treating the disease.
At present the cocktail of drugs administered through the chemotherapy route are not selective to the cancer cells and so they also attack healthy cells. In order for the treatment to be effective without causing unnecessary tissue damage, researchers have been looking for ways to specifically target the cancer cells in order to deliver the therapeutic agent that will kill the tumour.
An unexpected link between rhabdomyosarcoma and a particular form of a disease known as myasthenia gravis was recently discovered by University scientists. Research was being carried out at the University of Oxford amongst women suffering from spontaneous miscarriages caused by an autoimmune response to their own foetus. It was then discovered that the mothers were producing antibodies against a molecule on the surface of the foetal cells which was the same as that present on the surface of the rhabdomyosarcoma cells. Scientists at the University of Würzburg then made molecules that were smaller fragments of the antibody but which would still have the same attraction for the rhabdomyosarcoma cells as for the original antibody. A gene that encodes the fragments was then transferred into a bacteria containing the DNA for a toxin. An immunotoxin was then produced containing the antibody fragment and the toxin together which is able to target the sarcoma cells using the antibody fragment and kill them with the toxin.
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology