Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fingerprinting diseases

17.06.2004


José María Mato is a scientist at the new CIC-Biogune research centre in Zamudio (Bizkaia). For more than twenty years now he has been studying the liver disease known as steatohepatitis. This is a serious illness which develops when large amounts of fat are accumulate din the liver, and mat result in cirrhosis or, in the worst scenario, in cancerous tumours.



The greatest problem with this illness to date is that it cannot be diagnosed until the symptoms have already appeared and then it is normally too late, the disease being irreversible. José María Mato’s aim is to find a method which enables diagnosis in the initial phases of the illness, i.e. he is trying to find out which genes and proteins vary in this initial phases of the infirmity.

Mato had already identified a gene involved in the ailment but this did not prove to be enough. Now the proteins are his main target. The fact is that, although it is the genes that hold the relevant information, this data is later expressed in the proteins and it is these which really work inside the cells.


Effectively, the new challenge in biology is called proteomics. This is the science aimed at discovering what all the proteins are in the cell and how they function. In reality, it is considerably more complex than studying genes.

During the development of living organisms, the proteins in the cells vary. Likewise, they vary, for example, during any illness. Proteomics enables the observation of which proteins are expressed in each situation.

Moreover, with the new techniques, researchers can study the synthesis of hundreds of proteins in a short time. This is one of the great contributions of proteomics given that, until recently, the proteins had to be studied one by one. What’s more, they can be investigated at a speed that would have been unthinkable only a few years ago. This is why proteomics enables the stud of diseases from a perspective that is very different from the current one. Observing the pattern of protein expression in the cell, a kind of fingerprint for the illness can be obtained.

The aim of Mato is to find the “fingerprint” for steatohepatitis, see what proteins alter during the development of the disease and thus be able to develop a diagnostic chip in order to rapidly measure the amount of these very proteins in the blood of any patient. Proteomics has given great hope to scientists.

Aitziber Agirre | Basque research
Further information:
http://www.cicbiogune.com
http://www.basqueresearch.com/berria_irakurri.asp?Gelaxka=1_1&Berri_Kod=514&hizk=I

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>