Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bio-adhesive For Viscera And Tissues

01.06.2004


It is more convenient to glue parts together than to suture them. Even surgeons agree to that. They only need a good adhesive. Siberian researchers have created the third generation bio-adhesive and successfully tested it on animals.



Surgery is steadily improving methods for joining of slit parts. To solve the problem, biological adhesives were recently used. More often physicians use chemical compounds based on alpha cyanoacrylates, which do not provoke allergy or stimulate tumorogenesis. The Novosibirsk researchers, specialists of the Central Administrative Board for Research Center of Clinical and Experimental Medicine (Siberian Branch, Russian Academy of Medical Sciences), Central Administrative Board for Scientific Research Institute of Regional Pathology and Pathomorphology (Siberian Branch, Russian Academy of Medical Sciences) and Novosibirsk State Medical Academy (Ministry of Public Health of the Russian Federation) have developed a new adhesive composition called “Sulfacrylate” and tested it in practice.

“Sulfacrylate” is bio-adhesive of the third generation, it includes various esters of acrylic acid and its derivatives. Experiments were carried out on 142 animals: rats, outbred cats and Chinchilla rabbits. Under anaesthetic, in line with all rules of operating skill, a part of animals’ liver, spleen, kindey or bowels was ablated and then the injured tissues were glued together. The background groups consisted of the animals which were sutured after the operation. The researchers were interested in the influence of bio-adhesive on the tissues in the course of cicatrization, therefore the operated animals were slaughtered 3, 6 and 12 hours, a day, a week and a month after the operation to investigate the tissue status under the microscope.


The observations proved that the adhesive lays well on tissues and forms a polymer film. The film stops local bleeding and joins the slit parts hermetically. The zone of mortifing tissue, which always occurs in the area of the wound, was small and well-defined. “Sulfacrylate” contributed to formation of this zone, however its local toxic effect was over soon. In a month the wound closed up completely and the adhesive dissolved. Inflammation inevitably accompanies cicatrization, but the adhesive allowed to avoid festering. The animals from the background group had tissues injured not only during the operation, but also during suture, therefore the necrotic zone and local hemorrhages were much more extensive than in case of utilizing the adhesive, and cicatrization went through a stage of suppurative inflammation with microabscesses.

The benefits of “Sulfacrylate” are particularly noticeable in the cases when a lanced intestine is to be joined butt-to-butt. The researchers tested this joint for strength with the help of special pneumoequipment, which allows to measure the threshhold pressure: the adhesive joins stronger than the suture material. Glued intestinal loops can stand even severe treatment when getting preparations ready for microscopy. No stitch separated, no intestinal lumen was narrowed, no commissures occured either between intestinal loops, or adjacent organs, let alone peritonitis. Three months after the operation, the glued intestine remained elastic and did not become deformed, but the animals from the background group experienced all complications typical of intestines operations.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Cystic fibrosis alters the structure of mucus in airways
28.06.2017 | University of Iowa Health Care

nachricht Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>