A vaccine against allergies. This may be the eventual result of research at Uppsala university in Sweden. New findings are presented by Anna Ledin in her doctoral dissertation. She vaccinated dogs and rats against their own IgE antibodies, and shows that their allergic symptoms diminished.
The type of antibody called IgE is part of the body’s defense against parasites, but today it is best known for its key role in allergic reactions. IgE is what brings about an allergic reaction. Normally it constitutes 0.02 % of all antibodies in the blood, but people with allergies can have up to ten times as much. The best way for a person with allergies to avoid reactions is to avoid the substance that triggers the allergies. But if you are allergic to pollen it is not easy to avoid all the pollen produced by blossoming birch trees, for example, which can lead to asthma, hay fever, and/or eczema.
Anna Ledin belongs to a team of scientists at Uppsala University that is developing vaccines against allergies, under the direction of Professor Lars Hellman. Her dissertation is part of this project. She presents a new form of treatment for allergies in her study. By producing and injecting an IgE vaccine that looks like IgE, she demonstrates that the body perceives the vaccine as something alien. Antibodies are then produced to fight both IgE and the vaccine, bringing down the levels of IgE in the blood and reducing the allergic symptoms. The allergy vaccine has been tested on rats and dogs, and the results indicate a clear reduction of IgE levels after vaccination. Dogs are one of the few animals that have allergic reactions like humans, but it has been unclear just how IgE levels are related to their symptoms. A new method for monitoring IgE levels in the blood of dogs was developed by the research team, and it was found that dogs have extremely high levels of IgE, regardless of whether they were healthy or had allergic eczema, autoimmune disorders, or skin parasites. This makes it problematic to diagnose allergies merely on the basis of IgE from dog blood. What’s more, IgE was measured from three sets of puppies, and, unlike mature dogs, the puppies evinced low levels of IgE.
Anneli Waara | alfa
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
20.03.2018 | Physics and Astronomy
20.03.2018 | Physics and Astronomy
20.03.2018 | Earth Sciences