Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New “designer” steroid discovered in anonymously provided syringe

12.05.2004


Research News from Rapid Communications in Mass Spectrometry



A previously unknown synthetic “designer” steroid has been identified as tetrahydrogestrinone (THG). Researchers working out of the UCLA Olympic Analytical Laboratory in Los Angeles synthesized and characterized the “New Chemical Entity”, and proceeded to develop a rapid and accurate urine detection test for it. Details of the research are published this week in Rapid Communications in Mass Spectrometry.

In June 2003, a spent syringe having allegedly contained an undetectable anabolic steroid was anonymously provided to the United States Anti-Doping Agency (USADA), and the contents delivered to the research team in Los Angeles. The researchers, led by Don Catlin, detected an unfamiliar substance and deduced its chemical formula. They were then able to synthesize a compound with this formula, which they named tetrahydrogestrinone (THG) and which matched the unknown substance in the syringe.


Urine samples were purposely spiked with the newly identified THG and various analyses carried out to determine how the substance could be detected. Although it is not detectable by standard doping control screening, THG was found to be easily detectable by alternate methods. Once detection methods were established, the substance was administered to a baboon both intravenously and intramuscularly, and its excreted urine collected for analysis. It was determined that THG is detectable in urine after both IV and IM administration.

The designer drug identified in this study is different from anabolic steroids previously found in athletes’ urine samples. The Food and Drug Administration has warned that its use could pose health risks, and it cannot be legally marketed without approval.

Lead researcher Catlin attributes this discovery to the provision of crucial inside information, and believes it to be a valuable contribution to doping control. He says, “Now that there’s a test for THG, anyone using it can get caught, and it’s unlikely to be found again in an athlete’s urine sample.”

Jaida Harris | alfa
Further information:
http://www.interscience.wiley.com/rcm

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>