Six genes may hold the answer to whether a persons lymphoma is likely to respond to treatment. This finding by researchers at Stanford University School of Medicine could result in the first gene-based screen to identify people who need the most aggressive therapy.
When a person is diagnosed with diffuse large-B-cell lymphoma, doctors use a group of indicators called the International Prognostic Index, or IPI, which includes a persons age, tumor stage and blood markers to decide how to treat the cancer. Those with the highest IPI scores get the most aggressive therapy. However, two people with the same score may still react differently to treatment. One thought has been that a genetic screen may fine-tune the distinction between the most aggressive and least aggressive cancers.
"It makes a big difference in your treatment decisions if you think you have a high chance of success or if you dont," said Ronald Levy, MD, the Robert K. and Helen K. Summy Professor, who led the study. He said if doctors know a patient isnt likely to respond well to standard therapy, the patient may be a candidate for novel therapies undergoing clinical trials.
Amy Adams | EurekAlert!
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