Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HIV finds new way to play hide and seek

05.04.2004


The deadly virus HIV can mutate to prevent display of its components to immune cells, thus concealing itself from the body’s surveillance system and resulting in faster progression to AIDS, report Philip Goulder and colleagues in The Journal of Experimental Medicine. This has important implications for design of the long-sought-after vaccine for HIV.



When someone is infected with HIV, certain regions of viral proteins are chopped up and displayed by infected cells to their immune system, using platforms known as MHC molecules. These protein fragments are recognized by killer cells, which destroy the virus-infected cells. Viruses have evolved many clever mechanisms to avoid being detected in this way, including altering the protein fragments that our immune system recognizes. This study identifies for the first time, in the course of a natural human infection, HIV mutations outside of the regions that are recognized that actually prevent generation of the protein fragments. HIV can, apparently, alter its sequence so that the human chopping proteins can no longer grab onto the viral protein.

Cells infected with this mutant virus are not detected by the immune system, so the virus can replicate and increase in number. This was initially surprising, because the changes in the virus are in regions that are considered to be invisible to the immune system. But the new work indicates that vaccine designers must pay attention not only to the regions of HIV that are recognized by the immune system, but also to the nearby regions that allow the chopping proteins to do their work.



Contact: Dr Philip Goulder, The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford; 44-1865-281884; philip.goulder@clinical-medicine.oxford.ac.uk

Lynette Henry | EurekAlert!
Further information:
http://www.rupress.org/

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>