Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Most complete human blood-plasma proteome map to date unveiled


Researchers have identified an astounding 4,000 distinctive proteins in human blood plasma, a critical step toward cataloging biological markers for early diagnosis of cancer and other diseases.

"This is 10 times the number of proteins identified" and previously reported, said Richard D. Smith, a senior scientist and Battelle Fellow at the Department of Energy’s Pacific Northwest National Laboratory. The proteomics advance was announced Saturday at the American Association for the Advancement of Science annual meeting.

"Because there is huge interest in determining their utility as biomarkers for different diseases, I want to emphasize the large numbers of proteins now identified in plasma," said Smith, a Battelle Fellow at PNNL and director of the National Institutes of Health Proteomics Research Resource Center at PNNL’s Richland, Wash., campus.

"The large coverage is important because proteins from distressed cells in essentially any tissue that can leak into the blood stream might be found in plasma, given sufficiently sensitive methods of analysis," Smith said. "Thus, there is significant interest in cataloging the range of proteins present in blood plasma as potential biomarkers of disease states based upon their abundance change from normal levels."

A fast and sensitive proteomic analysis is necessary for such massive screenings of bodily fluids as needed to confidently identify biomarkers and to bring into sharp focus proteins that are signs of trouble to come.

Proteomics is akin to reading the proteins like tea leaves, minus the mystic, and generally involves measurements aimed at determining what proteins are present and at what levels. Smith’s group has developed an advanced form of mass spectrometry for this purpose: Fourier transform ion cyclotron resonance (FTICR). PNNL’s instrumentation can ransack a sample for proteins that defy detection by other means, having recently pushed the detection limits to about 10 zeptomoles, or on the order of 6,000 individual molecules, "allowing the detection of many previously undetected lower level proteins in plasma that are then candidates for biomarkers," Smith said.

The plasma-proteome advance is the latest in a string of milestones for the PNNL proteomics program over the past six months, as PNNL gears up to compete for the DOE’s multimillion-dollar Whole Proteome Analysis facility. This past summer the FTICR instrumentation developed at PNNL was named one of the 100 top inventions of the year by R&D Magazine, and in October NIH granted PNNL more than $10 million to establish its Research Resource center for proteomics.

PNNL is a DOE Office of Science research center that advances the fundamental understanding of complex systems and provides science-based solutions in national security, energy, chemistry, the biological sciences and environmental quality. Battelle, based in Columbus, Ohio, has operated PNNL for DOE since 1965.

Bill Cannon | PNNL
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>