Emory and CDC scientists explore why most breastfed infants of HIV-positive mothers resist infection
Although prolonged breastfeeding is well known to be a major route of transmission of HIV infection to infants and is estimated to cause one-third to one-half of new infant HIV-1 infections worldwide, the majority of breastfed infants with HIV-positive mothers remain uninfected, even after months of exposure.
Investigators at Emory University School of Medicine, the Centers for Disease Control and Prevention, the Emory Vaccine Center, and the University of Paris reviewed the scientific literature to pinpoint the reasons why many breastfed infants resist HIV, with the goal of devising future intervention strategies to prevent newborn infections. Their findings were published online in November and will be published in the December issue of The Lancet Infectious Diseases.
The researchers, led by Athena P. Kourtis, MD, PhD, MPH, formerly assistant professor of pediatrics at Emory University School of Medicine (now at Eastern Virginia Medical School and working at CDC) and Chris Ibegbu, PhD of the Emory Vaccine Center, identified several factors that have been cited by scientists as potentially enabling or preventing transmission of HIV through breastfeeding. Enabling factors could include the introduction of HIV into the gastrointestinal tract through a breach in the cell layer in the intestinal lining, or immune activation in the gastrointestinal tract could cause more HIV virus to reach this epithelial layer. Protective factors may include the hostile environment presented to viruses by the saliva and its various viral-inhibiting components.
The presence of HIV antibody in saliva already has been recognized in HIV-infected individuals, but scientists do not yet know whether this antibody is developed in non-infected breastfed infants, or whether it has a protective role against HIV. Natural killer (NK) cells or natural antibodies to HIV in exposed mucosal surfaces of infants could also play a role in resistance to HIV infection. Acquired T cell responses or specific antibody responses also may play a preventive role. Immune CD4 and CD8 T cells and antibodies in the mothers milk have been studied as factors that could account for this protection.
"In the developing world, where alternatives exist, breastfeeding is not recommended for HIV-positive mothers, which in part explains our lack of knowledge about resistance to infection," Dr. Kourtis says. "In the developing world, however, breastfeeding often is the only practical option for feeding infants, which makes understanding the mechanisms of HIV transmission a research priority. Inconsistent research findings about the role of anti-HIV antibodies and HIV-specific T cell responses have left significant gaps in our understanding of HIV transmission through breastfeeding."
Dr. Kourtis believes that advances in laboratory methods will help scientists clarify which immune factors are most important in HIV protection and help in the development of carefully planned intervention strategies. These could possibly include giving antibodies to the mother in late pregnancy or to the newborn, together with antiretroviral prophylaxis, she explains. Some of these approaches will be tested soon in large international trials.
Other scientists involved in the study included CDC scientists Salvatore Butera, PhD and Ann Duerr, MD, PhD, MPH and Laurent Belec, MD, PhD, of the Institut de Recherces Biomedicales des Cordeliers, Universite Paris.
Tia Webster | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Computer scientists use wave packet theory to develop realistic, detailed water wave simulations in real time. Their results will be presented at this year’s SIGGRAPH conference.
Think about the last time you were at a lake, river, or the ocean. Remember the ripples of the water, the waves crashing against the rocks, the wake following...
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...