Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue-engineered valves give diseased hearts new life

12.11.2003


American Heart Association meeting report



Heart valves engineered from patients’ own tissue may offer a new treatment for valvular heart disease, researchers reported today at the American Heart Association’s Scientific Sessions 2003.

"Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient’s own tissue, and so it does not cause an immunological reaction," said Pascal M. Dohmen, M.D., head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.


Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart.

The patients, whose average age was 44, had aortic valve disease. The aortic valve connects the heart’s left ventricle with the aorta, the main artery that distributes blood throughout the body. A diseased valve may either open or close improperly, and pressure can build in the ventricle, injuring the heart.

Doctors can treat the condition with drugs or by surgically replacing the patient’s aortic valve with a donor valve, a mechanical valve or the patient’s pulmonary valve. The pulmonary valve is between the right ventricle and the pulmonary artery. In a surgical "swap" called the Ross procedure, the abnormal aortic valve is replaced with the pulmonary valve, and the pulmonary valve is replaced with a donor valve.

Dohmen and colleagues engineered a new pulmonary valve from the patients’ own cells. They implanted the patients’ healthy pulmonary valve into the aortic position. Then they implanted the tissue-engineered valve in the right ventricular outflow tract, where the pulmonary valve originally was.

With up to three years of follow-up, the engineered valve’s performance was "excellent," Dohmen reported. Echocardiography showed that the valves were functioning normally; the valve leaflets or flaps appeared smooth and pliable and showed no signs of calcification.

The patients were discharged from the hospital earlier, and were in better condition than other patients. They had no post-operative fever, which is often found in patients receiving donor heart valves, Dohmen said. Furthermore, the recovery time was shorter.

To engineer the new valve leaflets, the investigators extracted a small portion of vein from the patients’ leg or arm. Then they grew endothelial cells from the vein on a donor valve scaffold in the laboratory. The scaffold had been stripped of cells, leaving only an elastin and collagen matrix for binding the patients’ cells.

"In animal studies, we have seen that this matrix or scaffold will be absorbed by the body," Dohmen said. "In the mean time, the patient’s cells will form a new scaffold. After about a year, the matrix is of the patients’ own material.

"The problem until now was to reconstruct the right ventricular outflow tract," he said. "You cannot do this with regular animal (pig) or human donor valves because they will calcify early or degenerate soon after implantation, especially in patients under the age of 60."

Dohmen limits the use of the tissue-engineered valves to adults up to 60 years of age, but plans to explore the growth potential of the valves, with the hope of using them in children with congenital heart disease.

The heart valve scaffold technique is still considered experimental, he said.


Co-authors are Simon Dushe, Alexander Lembcke, Dietmar Kivelitz, Holger Hotz and Wolfgang F. Konertz.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>