Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRC Study Shows Highly Active Anti-retroviral Therapy Dramatically Cuts Deaths From AIDS

17.10.2003


A dramatic increase in life expectancy for people infected with HIV has been achieved since the introduction of Highly Active Anti-Retroviral Therapy (HAART), say Medical Research Council (MRC) scientists today (Friday 17 October 2003).



New research conducted at the MRC Clinical Trials Unit in London and published in this week’s issue of The Lancet shows that in the first four years after the introduction of HAART, death rates from AIDS fell by over 80%.

More than 50,000 people in the UK are living with HIV and worldwide, more than 40 million people have been infected with the virus.


Anti-retroviral drugs work by attacking the virus (HIV) that causes AIDS, slowing the progression of the disease and prolonging life. HAART is the name given to anti-retroviral combination treatments that include three or more drugs.

Using data from CASCADE*, a large collaboration of 22 different studies across Europe, Australia and Canada, scientists led by Dr Kholoud Porter of the MRC Clinical Trials Unit assessed the effect of HAART on life expectancy and development of AIDS in people with a known date of HIV infection.

The researchers found that when HAART was introduced in 1997, death rates immediately halved. By 2001, death rates had been cut by over 80%. Over this four year period, use of HAART therapy increased from one in five patients to over half the people infected with HIV.

Before 1997, the risk of developing AIDS was much higher in those aged 45 years or older when they were infected with HIV compared with people who were 16-24 years old. The study found that older people infected with HIV no longer appear to have a reduced life expectancy compared with younger people.

However, the researchers also found that people with HIV who were infected through injecting drug-use were four times more likely to die of AIDS than men infected through sexual contact. Similarly, people infected through other routes, such as haemophiliacs, were three times more likely to die. The researchers suggest that these findings could be due to these groups of people spending less time on HAART, or benefiting less from therapy because of reduced adherence or other existing infections such as Heptatitis.

Dr Porter said: “The introduction of highly active anti-retroviral therapy has been a tremendous success. Before this therapy was introduced, about half of those infected were expected to live for ten years after diagnosis, much less if they were, say, 40 years old when infected. Now, people treated with these combinations of drugs can almost all expect to live at least ten years after diagnosis, regardless of their age at infection.

“However our findings do point to the importance of an early diagnosis so that people can access the best treatments at the right time. We also need to continue to explore what happens when therapy starts to fail, for example due to resistance to anti-retroviral drugs, if we are to maintain improved life expectancy for people living with HIV.”

The collaboration is funded through a grant from the European Union and has received additional funding from GlaxoSmithKline.

| alfa
Further information:
http://www.mrc.ac.uk

More articles from Health and Medicine:

nachricht A 'half-hearted' solution to one-sided heart failure
24.11.2017 | Boston Children's Hospital

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New proton record: Researchers measure magnetic moment with greatest possible precision

High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons

The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

IceCube experiment finds Earth can block high-energy particles from nuclear reactions

24.11.2017 | Physics and Astronomy

A 'half-hearted' solution to one-sided heart failure

24.11.2017 | Health and Medicine

Heidelberg Researchers Study Unique Underwater Stalactites

24.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>