Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRC Study Shows Highly Active Anti-retroviral Therapy Dramatically Cuts Deaths From AIDS

17.10.2003


A dramatic increase in life expectancy for people infected with HIV has been achieved since the introduction of Highly Active Anti-Retroviral Therapy (HAART), say Medical Research Council (MRC) scientists today (Friday 17 October 2003).



New research conducted at the MRC Clinical Trials Unit in London and published in this week’s issue of The Lancet shows that in the first four years after the introduction of HAART, death rates from AIDS fell by over 80%.

More than 50,000 people in the UK are living with HIV and worldwide, more than 40 million people have been infected with the virus.


Anti-retroviral drugs work by attacking the virus (HIV) that causes AIDS, slowing the progression of the disease and prolonging life. HAART is the name given to anti-retroviral combination treatments that include three or more drugs.

Using data from CASCADE*, a large collaboration of 22 different studies across Europe, Australia and Canada, scientists led by Dr Kholoud Porter of the MRC Clinical Trials Unit assessed the effect of HAART on life expectancy and development of AIDS in people with a known date of HIV infection.

The researchers found that when HAART was introduced in 1997, death rates immediately halved. By 2001, death rates had been cut by over 80%. Over this four year period, use of HAART therapy increased from one in five patients to over half the people infected with HIV.

Before 1997, the risk of developing AIDS was much higher in those aged 45 years or older when they were infected with HIV compared with people who were 16-24 years old. The study found that older people infected with HIV no longer appear to have a reduced life expectancy compared with younger people.

However, the researchers also found that people with HIV who were infected through injecting drug-use were four times more likely to die of AIDS than men infected through sexual contact. Similarly, people infected through other routes, such as haemophiliacs, were three times more likely to die. The researchers suggest that these findings could be due to these groups of people spending less time on HAART, or benefiting less from therapy because of reduced adherence or other existing infections such as Heptatitis.

Dr Porter said: “The introduction of highly active anti-retroviral therapy has been a tremendous success. Before this therapy was introduced, about half of those infected were expected to live for ten years after diagnosis, much less if they were, say, 40 years old when infected. Now, people treated with these combinations of drugs can almost all expect to live at least ten years after diagnosis, regardless of their age at infection.

“However our findings do point to the importance of an early diagnosis so that people can access the best treatments at the right time. We also need to continue to explore what happens when therapy starts to fail, for example due to resistance to anti-retroviral drugs, if we are to maintain improved life expectancy for people living with HIV.”

The collaboration is funded through a grant from the European Union and has received additional funding from GlaxoSmithKline.

| alfa
Further information:
http://www.mrc.ac.uk

More articles from Health and Medicine:

nachricht PET imaging tracks Zika virus infection, disease progression in mouse model
20.09.2017 | US Army Medical Research Institute of Infectious Diseases

nachricht 'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Molecular Force Sensors

20.09.2017 | Life Sciences

Producing electricity during flight

20.09.2017 | Power and Electrical Engineering

Tiny lasers from a gallery of whispers

20.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>