Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone cement only controls bacteria for a few days after the operation

10.10.2003


Dutch research has revealed that bone cement containing antibiotics can effectively control infections around prostheses but only during the first few days after the implantation. For the past 30 years bone cement, which affixes hip and knee prostheses to the bone, has contained antibiotics and from the start, the usefulness of this has been contested.



In a laboratory set-up, Hans Hendriks discovered that in the immediate vicinity of the antibiotic-containing bone cement, the antibiotic concentrations are particularly high. However, this is predominantly during the first few days after the application of the cement and the long-term release of the antibiotic seems to be less effective.

Hendriks investigated the release of antibiotics under simulated real-life conditions. He first of all investigated the antibiotic concentration in the cavity between the surface of the bone and the bone cement. In the human body this cavity is about 0.2 mm wide.


The antibiotic concentrations in the cavity were found to be 1000 times higher than the lethal dose for most bacteria. Experiments with different bacterial species led Hendriks to conclude that virtually no bacteria could survive in this environment. Three weeks later, the concentration of antibiotics had decreased to the extent that increasingly fewer bacteria were inhibited by these.

Placing the bone cement under stress did not affect the release of antibiotics. Walking on a cemented prosthesis results in the bone cement being subjected to periodic stress. Small cracks can arise as a consequence of this. As the surface of such a crack has not previously been in direct contact with body fluids it could form a new surface for the release of the antibiotic. Using an experimental set-up, Hendriks demonstrated that no new release occurs even after 5 to 10 years of walking around on a prosthesis.

For the past 30 years, bone cement has contained antibiotics to prevent and cure infections around implants. However, opinions were divided with respect to the effectiveness of this treatment as well as the associated risks. Furthermore, the exact mechanism by which the cement released the antibiotics was unclear. However, it has been established that more than eighty percent of the antibiotics can still be found in the bone cement years later. Knowledge about the release of the antibiotics could contribute to the development of new antibiotic carriers to control infections in orthopaedic surgery.

Sonja Jacobs | alfa
Further information:
http://www.nwo.nl

More articles from Health and Medicine:

nachricht Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>