Piero Anversa, M.D., director of the Cardiovascular Research Institute at New York Medical College, has demonstrated again that the heart has its own adult stem cells for regenerating heart muscle tissue following a coronary event. The research paper published in the September 19, 2003, issue of the journal Cell builds upon a study that appeared weeks ago in the September 2 Proceedings of the National Academy of Sciences.
The Cell study was conducted in Dr. Anversas laboratory by a team led by Dr. Anversa, Bernardo Nadal-Ginard, M.D., Ph.D., Annarosa Leri, M.D., and Jan Kajstura, Ph.D. "Until recently, the accepted paradigm in cardiac biology considered the adult mammalian heart a post-mitotic organ without regenerative capacity…that from shortly after birth to adulthood and senescence the heart has a relatively stable but slowly diminishing number of myocytes [heart muscle cells]…Evidence challenging the accepted wisdom has been slowly accumulating," they wrote.
Dr. Anversas investigation of heart failure has produced mounting evidence the heart can repair itself, debunking the notion that stem cells can be isolated only from adult tissues such as blood, skin, central nervous system, liver, gastrointestinal tract and skeletal muscle. In the current Cell paper, he and his colleagues utilized special cells isolated from adult rat hearts that have all the properties of cardiac progenitor cells. They injected an enriched mixture of the cells into ischemic hearts, where they gave rise to new myocytes as well as smooth muscle and endothelial cells that were structurally and functionally competent.
Donna E. Moriarty | EurekAlert!
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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